2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Roger S. Blumenthal; Pamela B. Morris; Mario Gaudino; Heather M. Johnson; Timothy S. Anderson; Vera A. Bittner; Ron Blankstein; La Princess C. Brewer; Leslie Cho; Sarah D. de Ferranti; Eugenia Gianos; Ty J. Gluckman; Kristen F. Gradney; Ijeoma Isiadinso; Donald M. Lloyd-Jones; Joel C. Marrs; Seth S. Martin; Kellie H. McLain; Laxmi S. Mehta; Samia Mora; Wudeneh M. Mulugeta; Pradeep Natarajan; Ann Marie Navar; Carl E. Orringer; Tamar S. Polonsky; Harmony R. Reynolds; Joseph J. Saseen; Michael D. Shapiro; Daniel E. Soffer; Sheila A. Tynes; Chloé D. Villavaso; Salim S. Virani; John T. Wilkins

doi:10.1016/j.jacc.2025.11.016

2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Roger S. Blumenthal
, Pamela B. Morris
, Mario Gaudino
, Heather M. Johnson
, Timothy S. Anderson
, Vera A. Bittner
, Ron Blankstein
, La Princess C. Brewer
, Leslie Cho
, Sarah D. de Ferranti
, Eugenia Gianos
, Ty J. Gluckman
, Kristen F. Gradney
, Ijeoma Isiadinso
, Donald M. Lloyd-Jones
, Joel C. Marrs
, Seth S. Martin
, Kellie H. McLain
, Laxmi S. Mehta
, Samia Mora

Wudeneh M. Mulugeta, Pradeep Natarajan, Ann Marie Navar, Carl E. Orringer, Tamar S. Polonsky, Harmony R. Reynolds, Joseph J. Saseen, Michael D. Shapiro, Daniel E. Soffer, Sheila A. Tynes, Chloé D. Villavaso, Salim S. Virani, John T. Wilkins

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Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

AIM: The "2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia" retires and replaces the "2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol." METHODS: A comprehensive literature search was conducted from October 2024 to December 2024 to identify clinical studies, systematic reviews and meta-analyses, and other evidence conducted on human participants that were published in English from MEDLINE (through PubMed), EMBASE, the Cochrane Library, Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. STRUCTURE: The focus of this clinical practice guideline is to address the evaluation, management, and monitoring of individuals with dyslipidemias, including high blood cholesterol, hypertriglyceridemia, and elevated lipoprotein(a).

Original language	English (US)
Pages (from-to)	2624-2757
Number of pages	134
Journal	Journal of the American College of Cardiology
Volume	87
Issue number	19
DOIs	https://doi.org/10.1016/j.jacc.2025.11.016
Publication status	Published - 19 May 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ACC/AHA clinical practice guideline
HDL
LDL
anticholesteremic agents
atherosclerosis
atherosclerotic disease
cardiovascular disease
cardiovascular diseases
cholesterol
drug interactions
dyslipidemia(s)
hydroxymethylglutaryl-CoA reductase inhibitors
hypercholesterolemia
hyperlipid(a)emia/s
hyperlipoproteinemia type II
hypertriglyceridemia
hypolipidemic agents
lipids
lipoprotein(a)
primary prevention
risk adjustment
risk assessment
risk factors
simvastatin
statin(s)
triglycerides

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10.1016/j.jacc.2025.11.016

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Blumenthal, R. S., Morris, P. B., Gaudino, M., Johnson, H. M., Anderson, T. S., Bittner, V. A., Blankstein, R., Brewer, L. P. C., Cho, L., de Ferranti, S. D., Gianos, E., Gluckman, T. J., Gradney, K. F., Isiadinso, I., Lloyd-Jones, D. M., Marrs, J. C., Martin, S. S., McLain, K. H., Mehta, L. S., ... Wilkins, J. T. (2026). 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Journal of the American College of Cardiology, 87(19), 2624-2757. https://doi.org/10.1016/j.jacc.2025.11.016

Blumenthal, Roger S. ; Morris, Pamela B. ; Gaudino, Mario et al. / 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia : A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. In: Journal of the American College of Cardiology. 2026 ; Vol. 87, No. 19. pp. 2624-2757.

@article{e5b848f65c42446aae3a1f438a586b7d,

title = "2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines",

abstract = "AIM: The {"}2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia{"} retires and replaces the {"}2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol.{"} METHODS: A comprehensive literature search was conducted from October 2024 to December 2024 to identify clinical studies, systematic reviews and meta-analyses, and other evidence conducted on human participants that were published in English from MEDLINE (through PubMed), EMBASE, the Cochrane Library, Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. STRUCTURE: The focus of this clinical practice guideline is to address the evaluation, management, and monitoring of individuals with dyslipidemias, including high blood cholesterol, hypertriglyceridemia, and elevated lipoprotein(a).",

keywords = "ACC/AHA clinical practice guideline, HDL, LDL, anticholesteremic agents, atherosclerosis, atherosclerotic disease, cardiovascular disease, cardiovascular diseases, cholesterol, drug interactions, dyslipidemia(s), hydroxymethylglutaryl-CoA reductase inhibitors, hypercholesterolemia, hyperlipid(a)emia/s, hyperlipoproteinemia type II, hypertriglyceridemia, hypolipidemic agents, lipids, lipoprotein(a), primary prevention, risk adjustment, risk assessment, risk factors, simvastatin, statin(s), triglycerides",

author = "Blumenthal, \{Roger S.\} and Morris, \{Pamela B.\} and Mario Gaudino and Johnson, \{Heather M.\} and Anderson, \{Timothy S.\} and Bittner, \{Vera A.\} and Ron Blankstein and Brewer, \{La Princess C.\} and Leslie Cho and \{de Ferranti\}, \{Sarah D.\} and Eugenia Gianos and Gluckman, \{Ty J.\} and Gradney, \{Kristen F.\} and Ijeoma Isiadinso and Lloyd-Jones, \{Donald M.\} and Marrs, \{Joel C.\} and Martin, \{Seth S.\} and McLain, \{Kellie H.\} and Mehta, \{Laxmi S.\} and Samia Mora and Mulugeta, \{Wudeneh M.\} and Pradeep Natarajan and Navar, \{Ann Marie\} and Orringer, \{Carl E.\} and Polonsky, \{Tamar S.\} and Reynolds, \{Harmony R.\} and Saseen, \{Joseph J.\} and Shapiro, \{Michael D.\} and Soffer, \{Daniel E.\} and Tynes, \{Sheila A.\} and Villavaso, \{Chlo{\'e} D.\} and Virani, \{Salim S.\} and Wilkins, \{John T.\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2026. Published by Elsevier Inc.",

year = "2026",

month = may,

day = "19",

doi = "10.1016/j.jacc.2025.11.016",

language = "English (US)",

volume = "87",

pages = "2624--2757",

journal = "Journal of the American College of Cardiology",

issn = "0735-1097",

publisher = "Elsevier Inc.",

number = "19",

}

Blumenthal, RS, Morris, PB, Gaudino, M, Johnson, HM, Anderson, TS, Bittner, VA, Blankstein, R, Brewer, LPC, Cho, L, de Ferranti, SD, Gianos, E, Gluckman, TJ, Gradney, KF, Isiadinso, I, Lloyd-Jones, DM, Marrs, JC, Martin, SS, McLain, KH, Mehta, LS, Mora, S, Mulugeta, WM, Natarajan, P, Navar, AM, Orringer, CE, Polonsky, TS, Reynolds, HR, Saseen, JJ, Shapiro, MD, Soffer, DE, Tynes, SA, Villavaso, CD, Virani, SS & Wilkins, JT 2026, '2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines', Journal of the American College of Cardiology, vol. 87, no. 19, pp. 2624-2757. https://doi.org/10.1016/j.jacc.2025.11.016

2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. / Blumenthal, Roger S.; Morris, Pamela B.; Gaudino, Mario et al.
In: Journal of the American College of Cardiology, Vol. 87, No. 19, 19.05.2026, p. 2624-2757.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia

T2 - A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

AU - Blumenthal, Roger S.

AU - Morris, Pamela B.

AU - Gaudino, Mario

AU - Johnson, Heather M.

AU - Anderson, Timothy S.

AU - Bittner, Vera A.

AU - Blankstein, Ron

AU - Brewer, La Princess C.

AU - Cho, Leslie

AU - de Ferranti, Sarah D.

AU - Gianos, Eugenia

AU - Gluckman, Ty J.

AU - Gradney, Kristen F.

AU - Isiadinso, Ijeoma

AU - Lloyd-Jones, Donald M.

AU - Marrs, Joel C.

AU - Martin, Seth S.

AU - McLain, Kellie H.

AU - Mehta, Laxmi S.

AU - Mora, Samia

AU - Mulugeta, Wudeneh M.

AU - Natarajan, Pradeep

AU - Navar, Ann Marie

AU - Orringer, Carl E.

AU - Polonsky, Tamar S.

AU - Reynolds, Harmony R.

AU - Saseen, Joseph J.

AU - Shapiro, Michael D.

AU - Soffer, Daniel E.

AU - Tynes, Sheila A.

AU - Villavaso, Chloé D.

AU - Virani, Salim S.

AU - Wilkins, John T.

PY - 2026/5/19

Y1 - 2026/5/19

N2 - AIM: The "2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia" retires and replaces the "2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol." METHODS: A comprehensive literature search was conducted from October 2024 to December 2024 to identify clinical studies, systematic reviews and meta-analyses, and other evidence conducted on human participants that were published in English from MEDLINE (through PubMed), EMBASE, the Cochrane Library, Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. STRUCTURE: The focus of this clinical practice guideline is to address the evaluation, management, and monitoring of individuals with dyslipidemias, including high blood cholesterol, hypertriglyceridemia, and elevated lipoprotein(a).

AB - AIM: The "2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia" retires and replaces the "2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol." METHODS: A comprehensive literature search was conducted from October 2024 to December 2024 to identify clinical studies, systematic reviews and meta-analyses, and other evidence conducted on human participants that were published in English from MEDLINE (through PubMed), EMBASE, the Cochrane Library, Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. STRUCTURE: The focus of this clinical practice guideline is to address the evaluation, management, and monitoring of individuals with dyslipidemias, including high blood cholesterol, hypertriglyceridemia, and elevated lipoprotein(a).

KW - ACC/AHA clinical practice guideline

KW - HDL

KW - LDL

KW - anticholesteremic agents

KW - atherosclerosis

KW - atherosclerotic disease

KW - cardiovascular disease

KW - cardiovascular diseases

KW - cholesterol

KW - drug interactions

KW - dyslipidemia(s)

KW - hydroxymethylglutaryl-CoA reductase inhibitors

KW - hypercholesterolemia

KW - hyperlipid(a)emia/s

KW - hyperlipoproteinemia type II

KW - hypertriglyceridemia

KW - hypolipidemic agents

KW - lipids

KW - lipoprotein(a)

KW - primary prevention

KW - risk adjustment

KW - risk assessment

KW - risk factors

KW - simvastatin

KW - statin(s)

KW - triglycerides

UR - https://www.scopus.com/pages/publications/105039600046

U2 - 10.1016/j.jacc.2025.11.016

DO - 10.1016/j.jacc.2025.11.016

M3 - Article

C2 - 41824590

AN - SCOPUS:105039600046

SN - 0735-1097

VL - 87

SP - 2624

EP - 2757

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 19

ER -

Blumenthal RS, Morris PB, Gaudino M, Johnson HM, Anderson TS, Bittner VA et al. 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Journal of the American College of Cardiology. 2026 May 19;87(19):2624-2757. doi: 10.1016/j.jacc.2025.11.016

2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Abstract

UN SDGs

Keywords

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