TY - JOUR
T1 - 5-FU induced acute toxic leukoencephalopathy
T2 - Early recognition and reversibility on DWI-MRI
AU - Anwar, Shayan Sirat Maheen
AU - Mubarak, Fatima
AU - Sajjad, Zafar
AU - Azeemuddin, Muhammad
PY - 2014
Y1 - 2014
N2 - Acute toxic leukoencephalopathy (ATL) is a rare adverse effect of 5-Fluorouracil (5-FU) chemotherapeutic agent. It is imperative for the radiologist to confidently identify the white matter changes caused by this agent in case of toxicity. This will help in early detection and appropriate management of patient, as the condition is reversible both clinically and on imaging. We report a case of a 29 years old gentleman, known case of carcinoma of esophagus who suffered from acute toxic leukoencephalopathy secondary to leukotoxic therapeutic agent 5-FU, and illustrate the reversible imaging findings of this condition on withdrawal of the inciting agent.
AB - Acute toxic leukoencephalopathy (ATL) is a rare adverse effect of 5-Fluorouracil (5-FU) chemotherapeutic agent. It is imperative for the radiologist to confidently identify the white matter changes caused by this agent in case of toxicity. This will help in early detection and appropriate management of patient, as the condition is reversible both clinically and on imaging. We report a case of a 29 years old gentleman, known case of carcinoma of esophagus who suffered from acute toxic leukoencephalopathy secondary to leukotoxic therapeutic agent 5-FU, and illustrate the reversible imaging findings of this condition on withdrawal of the inciting agent.
KW - 5-FU
KW - Diffussion weighted imaging (DWI)
KW - MRI
KW - Toxic leukoencephalopathy
UR - http://www.scopus.com/inward/record.url?scp=84907447414&partnerID=8YFLogxK
M3 - Article
C2 - 24718016
AN - SCOPUS:84907447414
SN - 1022-386X
VL - 24
SP - S8-S10
JO - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
JF - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
ER -