68Ga-DOTA-peptide PET/CT for radiotherapy planning and evaluating treatment response in the management of meningiomas

Sharjeel Usmani; Anjali Jain; Syed Furqan Hashmi; Layth Mula-Hussain; Khulood Al Riyami; Sofiullah Abubakar; Muhammad Shahzad Shamim

doi:10.47391/JPMA.23-44

68Ga-DOTA-peptide PET/CT for radiotherapy planning and evaluating treatment response in the management of meningiomas

Sharjeel Usmani, Anjali Jain, Syed Furqan Hashmi, Layth Mula-Hussain, Khulood Al Riyami, Sofiullah Abubakar, Muhammad Shahzad Shamim

Section of Neurosurgery, Department of Surgery, Medical College, Pakistan

Research output: Contribution to journal › Article › peer-review

Abstract

Meningiomas overexpress somatostatin receptors (SSTR). PET imaging with SSTR ligands such as 68Ga-DOTApeptide has recently shown high diagnostic accuracy in identification of meningiomas due to lack of normal bone and brain activity. PET-derived parameters, especially gross tumour volume (GTV) delineation improves interobserver variability and appears to be particularly promising for RT planning. The potential strength of 68Ga- DOTA in the ongoing assessment of treatment response and disease progression in meningioma, particularly in the post-surgical and post-radiation settings is encouraging. More prospective randomized studies with large cohorts of patients are required to define the effective role of this modality.

Original language	English
Pages (from-to)	1340-1343
Number of pages	4
Journal	Journal of the Pakistan Medical Association
Volume	73
Issue number	6
DOIs	https://doi.org/10.47391/JPMA.23-44
Publication status	Published - Jun 2023

Keywords

177Lu-DOTATATE
68Ga-DOTA PET/CT
Meningioma
PET/CT
radiotherapy planning

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title = "68Ga-DOTA-peptide PET/CT for radiotherapy planning and evaluating treatment response in the management of meningiomas",

abstract = "Meningiomas overexpress somatostatin receptors (SSTR). PET imaging with SSTR ligands such as 68Ga-DOTApeptide has recently shown high diagnostic accuracy in identification of meningiomas due to lack of normal bone and brain activity. PET-derived parameters, especially gross tumour volume (GTV) delineation improves interobserver variability and appears to be particularly promising for RT planning. The potential strength of 68Ga- DOTA in the ongoing assessment of treatment response and disease progression in meningioma, particularly in the post-surgical and post-radiation settings is encouraging. More prospective randomized studies with large cohorts of patients are required to define the effective role of this modality.",

keywords = "177Lu-DOTATATE, 68Ga-DOTA PET/CT, Meningioma, PET/CT, radiotherapy planning",

author = "Sharjeel Usmani and Anjali Jain and Hashmi, {Syed Furqan} and Layth Mula-Hussain and {Al Riyami}, Khulood and Sofiullah Abubakar and Shamim, {Muhammad Shahzad}",

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T1 - 68Ga-DOTA-peptide PET/CT for radiotherapy planning and evaluating treatment response in the management of meningiomas

AU - Usmani, Sharjeel

AU - Jain, Anjali

AU - Hashmi, Syed Furqan

AU - Mula-Hussain, Layth

AU - Al Riyami, Khulood

AU - Abubakar, Sofiullah

AU - Shamim, Muhammad Shahzad

PY - 2023/6

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N2 - Meningiomas overexpress somatostatin receptors (SSTR). PET imaging with SSTR ligands such as 68Ga-DOTApeptide has recently shown high diagnostic accuracy in identification of meningiomas due to lack of normal bone and brain activity. PET-derived parameters, especially gross tumour volume (GTV) delineation improves interobserver variability and appears to be particularly promising for RT planning. The potential strength of 68Ga- DOTA in the ongoing assessment of treatment response and disease progression in meningioma, particularly in the post-surgical and post-radiation settings is encouraging. More prospective randomized studies with large cohorts of patients are required to define the effective role of this modality.

AB - Meningiomas overexpress somatostatin receptors (SSTR). PET imaging with SSTR ligands such as 68Ga-DOTApeptide has recently shown high diagnostic accuracy in identification of meningiomas due to lack of normal bone and brain activity. PET-derived parameters, especially gross tumour volume (GTV) delineation improves interobserver variability and appears to be particularly promising for RT planning. The potential strength of 68Ga- DOTA in the ongoing assessment of treatment response and disease progression in meningioma, particularly in the post-surgical and post-radiation settings is encouraging. More prospective randomized studies with large cohorts of patients are required to define the effective role of this modality.

KW - 177Lu-DOTATATE

KW - 68Ga-DOTA PET/CT

KW - Meningioma

KW - PET/CT

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68Ga-DOTA-peptide PET/CT for radiotherapy planning and evaluating treatment response in the management of meningiomas

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Keywords

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