TY - JOUR
T1 - A cluster randomised controlled trial to reduce respiratory effects of cotton dust exposure among textile workers
T2 - the MultiTex RCT study
AU - Nafees, Asaad Ahmed
AU - Allana, Asad
AU - Kadir, Muhammad Masood
AU - Potts, James
AU - Minelli, Cosetta
AU - Semple, Sean
AU - De Matteis, Sara
AU - Burney, Peter
AU - Cullinan, Paul
N1 - Publisher Copyright:
© The authors 2024.
PY - 2024
Y1 - 2024
N2 - Background We determined the effectiveness of an intervention to reduce cotton dust-related respiratory symptoms and improve lung function of textile workers. Methods We undertook a cluster randomised controlled trial at 38 textile mills in Karachi, Pakistan. The intervention comprised: training in occupational health for workers and managers, formation of workplace committees to promote a health and safety plan that included wet mopping and safe disposal of cotton dust, provision of simple face masks, and further publicity about the risks from cotton dust. Participating mills were randomised following baseline data collection. The impact of the intervention was measured through surveys at 3, 12 and 18 months using questionnaires, spirometry and dust measurements. The primary outcomes were 1) changes in prevalence of a composite respiratory symptom variable, 2) changes in post-bronchodilator percentage predicted forced expiratory volume in 1 s (FEV1) and 3) changes in cotton dust levels. These were assessed using two-level mixed effects linear and logistic regression. Results Of 2031 participants recruited at baseline, 807 (40%) were available at the third follow-up. At that point, workers in the intervention arm were more likely to report an improvement in respiratory symptoms (OR 1.58, 95% CI 1.06–2.36) and lung function (FEV1 % pred: β 1.31%, 95% CI 0.04–2.57%). Personal dust levels decreased, more so in intervention mills, although we did not observe this in adjusted models due to the small number of samples. Conclusion We found the intervention to be effective in improving the respiratory health of textile workers and recommend scaling-up of such simple and feasible interventions in low- and middle-income countries.
AB - Background We determined the effectiveness of an intervention to reduce cotton dust-related respiratory symptoms and improve lung function of textile workers. Methods We undertook a cluster randomised controlled trial at 38 textile mills in Karachi, Pakistan. The intervention comprised: training in occupational health for workers and managers, formation of workplace committees to promote a health and safety plan that included wet mopping and safe disposal of cotton dust, provision of simple face masks, and further publicity about the risks from cotton dust. Participating mills were randomised following baseline data collection. The impact of the intervention was measured through surveys at 3, 12 and 18 months using questionnaires, spirometry and dust measurements. The primary outcomes were 1) changes in prevalence of a composite respiratory symptom variable, 2) changes in post-bronchodilator percentage predicted forced expiratory volume in 1 s (FEV1) and 3) changes in cotton dust levels. These were assessed using two-level mixed effects linear and logistic regression. Results Of 2031 participants recruited at baseline, 807 (40%) were available at the third follow-up. At that point, workers in the intervention arm were more likely to report an improvement in respiratory symptoms (OR 1.58, 95% CI 1.06–2.36) and lung function (FEV1 % pred: β 1.31%, 95% CI 0.04–2.57%). Personal dust levels decreased, more so in intervention mills, although we did not observe this in adjusted models due to the small number of samples. Conclusion We found the intervention to be effective in improving the respiratory health of textile workers and recommend scaling-up of such simple and feasible interventions in low- and middle-income countries.
UR - http://www.scopus.com/inward/record.url?scp=85182954960&partnerID=8YFLogxK
U2 - 10.1183/13993003.01028-2023
DO - 10.1183/13993003.01028-2023
M3 - Article
C2 - 37857425
AN - SCOPUS:85182954960
SN - 0903-1936
VL - 63
JO - European Respiratory Journal
JF - European Respiratory Journal
IS - 1
M1 - 2301028
ER -