A comparison of insulin lispro Mix25™ and human insulin 30/70 in the treatment of type 2 diabetes during Ramadan

V. Mattoo, Z. Milicevic, J. K. Malone, M. Schwarzenhofer, A. Ekangaki, L. K. Levitt, L. H.C. Liong, N. Rais, H. Tounsi, Hussien El Damassy, Mohamed Abdel Maboud, Megahed Aboul Magd, Abdel Raouf Rashwan, Aqeel H. Malbari, Mahendra H. Patel, Hasnain L. Patel, Altaf L. Patel, Jamal Ahmad, Anand Koppad, Nidhi ShuklaRokiah Pendek, Cheong Guan Ooi, Zainab Abu Kassim, Siew Pheng Chan, Fen Lee Hew, Ikram Shah Ismail, Mafauzy Mohamed, Wan Mohamad Wan Bebakar, Malik Mumtaz, Mohammed Reida Ababou, Javed Akram, Shahzad Sarwar, Abdul Basit, Muhammad Qamar Masood, Muhammad Zafar Iqbal Hydrie, Abdul Jabbar, Fatirna Hussain, Chung Horn Lee, Yuan Tud Chen, Shu Chuan Vanessa Au, N. S. Levitt, Steven Grant Soule, Amr A.Hamid Saleh, Renuka Marwah, Ritika Bajaj, Asim Awan, Laudi Gerber, Petrus Lodewyk Du Toit

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)

Abstract

Objective: To compare insulin lispro Mix25 and human insulin 30/70 with regard to their effect on morning and evening postprandial glucose (PPG) control, and on average daily blood-glucose (BG), in patients with Type 2 diabetes who wish to fast during Ramadan. Method: Insulin lispro Mix25 and human insulin 30/70 were compared in an open-label, multicenter, randomised, crossover study involving 151 patients. Each treatment period had a duration of 14 days during which the patients self-monitored their BG before and 2 h after the main meals on any 3 days within the last 5 days of each treatment period. Results: The 2 h PPG excursion following the main evening meal after sunset was significantly lower with insulin lispro Mix25 (3.4±2.9 mmol/l) compared with human insulin 30/70 (4.0±3.2 mmol/l, P=0.007). The evening pre-meal fasting BG values were also lower with insulin lispro Mix25 (7.1±2.2 mmol/l) versus human insulin 30/70 (7.5±2.6 mmol/l, P=0.034). The average daily BG concentration was 9.5±2.4 mmol/l during treatment with insulin lispro Mix25 versus 10.1±2.5 mmol/l with human insulin 30/70 given in identical doses (P=0.004). Conclusion: When compared with human insulin 30/70, treatment of insulin-requiring Type 2 patients with insulin lispro Mix25 during Ramadan resulted in better average daily glycaemia, and better BG control before and after the evening meal. Insulin lispro Mix25 should be considered as a therapeutic option during Ramadan.

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume59
Issue number2
DOIs
Publication statusPublished - 1 Feb 2003
Externally publishedYes

Keywords

  • Fasting
  • Insulin
  • Lispro
  • Postprandial glucose control
  • Ramadan
  • Type 2 diabetes

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