A race against time: Reduced azithromycin susceptibility in Salmonella enterica serovar Typhi in Pakistan

Junaid Iqbal, Irum F. Dehraj, Megan E. Carey, Zoe A. Dyson, Denise Garrett, Jessica C. Seidman, Furqan Kabir, Senjuti Saha, Stephen Baker, Farah N. Qamar

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Antimicrobial resistance is an ongoing issue in the treatment of typhoid fever. Resistance to first-line antimicrobials and extensively drug resistant (XDR) Salmonella Typhi isolates in Pakistan have left azithromycin as the only remaining effective oral treatment. Here, we report the emergence of organisms with a single point mutation in acrB gene, implicated in azithromycin resistance, in a S. Typhi isolate from Pakistan. The isolation of this organism is worrisome and highlights the significance of the introduction of typhoid conjugate vaccine in South Asia.

Original languageEnglish
Article numbere00215-20
JournalmSphere
Volume5
Issue number4
DOIs
Publication statusPublished - 1 Jul 2020

Keywords

  • Antimicrobial resistance
  • Azithromycin higher MIC
  • Pakistan
  • Salmonella typhi
  • Typhoid fever

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