A race against time: Reduced azithromycin susceptibility in Salmonella enterica serovar Typhi in Pakistan

Junaid Iqbal; Irum F. Dehraj; Megan E. Carey; Zoe A. Dyson; Denise Garrett; Jessica C. Seidman; Furqan Kabir; Senjuti Saha; Stephen Baker; Farah N. Qamar

doi:10.1128/MSPHERE.00215-20

A race against time: Reduced azithromycin susceptibility in Salmonella enterica serovar Typhi in Pakistan

Junaid Iqbal
, Irum F. Dehraj
, Megan E. Carey
, Zoe A. Dyson
, Denise Garrett
, Jessica C. Seidman
, Furqan Kabir
, Senjuti Saha
, Stephen Baker
, Farah N. Qamar

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Antimicrobial resistance is an ongoing issue in the treatment of typhoid fever. Resistance to first-line antimicrobials and extensively drug resistant (XDR) Salmonella Typhi isolates in Pakistan have left azithromycin as the only remaining effective oral treatment. Here, we report the emergence of organisms with a single point mutation in acrB gene, implicated in azithromycin resistance, in a S. Typhi isolate from Pakistan. The isolation of this organism is worrisome and highlights the significance of the introduction of typhoid conjugate vaccine in South Asia.

Original language	English (US)
Article number	e00215-20
Journal	mSphere
Volume	5
Issue number	4
DOIs	https://doi.org/10.1128/MSPHERE.00215-20
Publication status	Published - 1 Jul 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antimicrobial resistance
Azithromycin higher MIC
Pakistan
Salmonella typhi
Typhoid fever

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10.1128/MSPHERE.00215-20

Cite this

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title = "A race against time: Reduced azithromycin susceptibility in Salmonella enterica serovar Typhi in Pakistan",

abstract = "Antimicrobial resistance is an ongoing issue in the treatment of typhoid fever. Resistance to first-line antimicrobials and extensively drug resistant (XDR) Salmonella Typhi isolates in Pakistan have left azithromycin as the only remaining effective oral treatment. Here, we report the emergence of organisms with a single point mutation in acrB gene, implicated in azithromycin resistance, in a S. Typhi isolate from Pakistan. The isolation of this organism is worrisome and highlights the significance of the introduction of typhoid conjugate vaccine in South Asia.",

keywords = "Antimicrobial resistance, Azithromycin higher MIC, Pakistan, Salmonella typhi, Typhoid fever",

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doi = "10.1128/MSPHERE.00215-20",

language = "English (US)",

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T1 - A race against time

T2 - Reduced azithromycin susceptibility in Salmonella enterica serovar Typhi in Pakistan

AU - Iqbal, Junaid

AU - Dehraj, Irum F.

AU - Carey, Megan E.

AU - Dyson, Zoe A.

AU - Garrett, Denise

AU - Seidman, Jessica C.

AU - Kabir, Furqan

AU - Saha, Senjuti

AU - Baker, Stephen

AU - Qamar, Farah N.

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Antimicrobial resistance is an ongoing issue in the treatment of typhoid fever. Resistance to first-line antimicrobials and extensively drug resistant (XDR) Salmonella Typhi isolates in Pakistan have left azithromycin as the only remaining effective oral treatment. Here, we report the emergence of organisms with a single point mutation in acrB gene, implicated in azithromycin resistance, in a S. Typhi isolate from Pakistan. The isolation of this organism is worrisome and highlights the significance of the introduction of typhoid conjugate vaccine in South Asia.

AB - Antimicrobial resistance is an ongoing issue in the treatment of typhoid fever. Resistance to first-line antimicrobials and extensively drug resistant (XDR) Salmonella Typhi isolates in Pakistan have left azithromycin as the only remaining effective oral treatment. Here, we report the emergence of organisms with a single point mutation in acrB gene, implicated in azithromycin resistance, in a S. Typhi isolate from Pakistan. The isolation of this organism is worrisome and highlights the significance of the introduction of typhoid conjugate vaccine in South Asia.

KW - Antimicrobial resistance

KW - Azithromycin higher MIC

KW - Pakistan

KW - Salmonella typhi

KW - Typhoid fever

UR - https://www.scopus.com/pages/publications/85088447015

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DO - 10.1128/MSPHERE.00215-20

M3 - Article

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AN - SCOPUS:85088447015

SN - 2379-5042

VL - 5

JO - mSphere

JF - mSphere

IS - 4

M1 - e00215-20

ER -

A race against time: Reduced azithromycin susceptibility in Salmonella enterica serovar Typhi in Pakistan

Abstract

UN SDGs

Keywords

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