A study on performance of two serological assays for diagnosis of leprosy patients

Om Parkash; V. Chaturvedi; B. K. Girdhar; U. Sengupta

doi:10.5935/0305-7518.19950004

A study on performance of two serological assays for diagnosis of leprosy patients

Om Parkash, V. Chaturvedi, B. K. Girdhar, U. Sengupta

Research output: Contribution to journal › Article › peer-review

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Abstract

We compared 2 serological tests for the diagnosis of leprosy to test their performances. The tests include the serum antibody competition test (SACT) for the detection of antibodies to Mycobacterium leprae-specific epitope on 35 KDa protein molecule, and M. leprae gelatin particle agglutination assay (MLPA), for the detection of antiphenolic glycolipid-1 (PGL-1) antibodies. In both the assays a higher serological positivity was seen amongst multibacillary (MB) patients than those in paucibacillary (PB) patients. Taking all leprosy patients together, the sensitivity of SACT (59.7%) was observed to be statistically comparable to that of MLPA (66.9%), However, SACT proved to be more specific (97.7%) than MLPA (75.0%). The agreement between these 2 assays was observed to be moderate.

Original language	English (UK)
Pages (from-to)	26-30
Number of pages	5
Journal	Leprosy Review
Volume	66
Issue number	1
DOIs	https://doi.org/10.5935/0305-7518.19950004
Publication status	Published - 1995
Externally published	Yes

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title = "A study on performance of two serological assays for diagnosis of leprosy patients",

abstract = "We compared 2 serological tests for the diagnosis of leprosy to test their performances. The tests include the serum antibody competition test (SACT) for the detection of antibodies to Mycobacterium leprae-specific epitope on 35 KDa protein molecule, and M. leprae gelatin particle agglutination assay (MLPA), for the detection of antiphenolic glycolipid-1 (PGL-1) antibodies. In both the assays a higher serological positivity was seen amongst multibacillary (MB) patients than those in paucibacillary (PB) patients. Taking all leprosy patients together, the sensitivity of SACT (59.7\%) was observed to be statistically comparable to that of MLPA (66.9\%), However, SACT proved to be more specific (97.7\%) than MLPA (75.0\%). The agreement between these 2 assays was observed to be moderate.",

author = "Om Parkash and V. Chaturvedi and Girdhar, \{B. K.\} and U. Sengupta",

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doi = "10.5935/0305-7518.19950004",

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AU - Parkash, Om

AU - Chaturvedi, V.

AU - Girdhar, B. K.

AU - Sengupta, U.

PY - 1995

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N2 - We compared 2 serological tests for the diagnosis of leprosy to test their performances. The tests include the serum antibody competition test (SACT) for the detection of antibodies to Mycobacterium leprae-specific epitope on 35 KDa protein molecule, and M. leprae gelatin particle agglutination assay (MLPA), for the detection of antiphenolic glycolipid-1 (PGL-1) antibodies. In both the assays a higher serological positivity was seen amongst multibacillary (MB) patients than those in paucibacillary (PB) patients. Taking all leprosy patients together, the sensitivity of SACT (59.7%) was observed to be statistically comparable to that of MLPA (66.9%), However, SACT proved to be more specific (97.7%) than MLPA (75.0%). The agreement between these 2 assays was observed to be moderate.

AB - We compared 2 serological tests for the diagnosis of leprosy to test their performances. The tests include the serum antibody competition test (SACT) for the detection of antibodies to Mycobacterium leprae-specific epitope on 35 KDa protein molecule, and M. leprae gelatin particle agglutination assay (MLPA), for the detection of antiphenolic glycolipid-1 (PGL-1) antibodies. In both the assays a higher serological positivity was seen amongst multibacillary (MB) patients than those in paucibacillary (PB) patients. Taking all leprosy patients together, the sensitivity of SACT (59.7%) was observed to be statistically comparable to that of MLPA (66.9%), However, SACT proved to be more specific (97.7%) than MLPA (75.0%). The agreement between these 2 assays was observed to be moderate.

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A study on performance of two serological assays for diagnosis of leprosy patients

Abstract

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