A Study on the Geophylogeny of Clinical and Environmental Vibrio cholerae in Kenya

John Kiiru, Ankur Mutreja, Ahmed Abade Mohamed, Racheal W. Kimani, Joyce Mwituria, Robert Onsare Sanaya, Jane Muyodi, Gunturu Revathi, Julian Parkhill, Nicholas Thomson, Gordon Dougan, Samuel Kariuki

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Cholera remains a significant public health challenge in many sub-Saharan countries including Kenya. We have performed a combination of phylogenetic and phenotypic analysis based on whole genome DNA sequences derived from 40 environmental and 57 clinical V. cholerae from different regions of Kenya isolated between 2005 and 2010. Some environmental and all clinical isolates mapped back onto wave three of the monophyletic seventh pandemic V. cholerae El Tor phylogeny but other environmental isolates were phylogenetically very distinct. Thus, the genomes of the Kenyan V. cholerae O1 El Tor isolates are clonally related to other El Tor V. cholerae isolated elsewhere in the world and similarly harbour antibiotic resistance-associated STX elements. Further, the Kenyan O1 El Tor isolates fall into two distinct clades that may have entered Kenya independently.

Original languageEnglish
Article numbere74829
JournalPLoS ONE
Issue number9
Publication statusPublished - 16 Sept 2013


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