Aberrant functional connectivity for diagnosis of major depressive disorder: a discriminant analysis.

Longlong Cao, Shuixia Guo, Zhimin Xue, Yong Hu, Haihong Liu, Tumbwene E. Mwansisya, Weidan Pu, B. Yang, Chang Liu, Jianfeng Feng, Eric Y.H. Chen, Zhening Liu

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Aberrant brain functional connectivity patterns have been reported in major depressive disorder (MDD). It is unknown whether they can be used in discriminant analysis for diagnosis of MDD. In the present study we examined the efficiency of discriminant analysis of MDD by individualized computer-assisted diagnosis. Based on resting-state functional magnetic resonance imaging data, a new approach was adopted to investigate functional connectivity changes in 39 MDD patients and 37 well-matched healthy controls. By using the proposed feature selection method, we identified significant altered functional connections in patients. They were subsequently applied to our analysis as discriminant features using a support vector machine classification method. Furthermore, the relative contribution of functional connectivity was estimated. After subset selection of high-dimension features, the support vector machine classifier reached up to approximately 84% with leave-one-out training during the discrimination process. Through summarizing the classification contribution of functional connectivities, we obtained four obvious contribution modules: inferior orbitofrontal module, supramarginal gyrus module, inferior parietal lobule-posterior cingulated gyrus module and middle temporal gyrus-inferior temporal gyrus module. The experimental results demonstrated that the proposed method is effective in discriminating MDD patients from healthy controls. Functional connectivities might be useful as new biomarkers to assist clinicians in computer auxiliary diagnosis of MDD.

Original languageEnglish
Pages (from-to)110-119
Number of pages10
JournalPsychiatry and Clinical Neurosciences
Volume68
Issue number2
DOIs
Publication statusPublished - Feb 2014

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