Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Alzheimer’s Disease Neuroimaging Initiative (ADNI); Dominantly Inherited Alzheimer Network (DIAN) Study Group; Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group

doi:10.1038/s41467-021-25492-9

Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dominantly Inherited Alzheimer Network (DIAN) Study Group, Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer’s disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD. We developed a model that predicts brain age from resting state (rs)-fMRI data, and assessed whether genetic determinants of AD, as well as beta-amyloid (Aβ) pathology, can accelerate brain aging. Using data from 1340 cognitively unimpaired participants between 18–94 years of age from multiple sites, we showed that topological properties of graphs constructed from rs-fMRI can predict chronological age across the lifespan. Application of our predictive model to the context of pre-clinical AD revealed that the pre-symptomatic phase of autosomal dominant AD includes acceleration of functional brain aging. This association was stronger in individuals having significant Aβ pathology.

Original language	English (US)
Article number	5346
Journal	Nature Communications
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41467-021-25492-9
Publication status	Published - Dec 2021
Externally published	Yes

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10.1038/s41467-021-25492-9

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Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dominantly Inherited Alzheimer Network (DIAN) Study Group, & Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group (2021). Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease. Nature Communications, 12(1), Article 5346. https://doi.org/10.1038/s41467-021-25492-9

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title = "Accelerated functional brain aging in pre-clinical familial Alzheimer{\textquoteright}s disease",

abstract = "Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer{\textquoteright}s disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD. We developed a model that predicts brain age from resting state (rs)-fMRI data, and assessed whether genetic determinants of AD, as well as beta-amyloid (Aβ) pathology, can accelerate brain aging. Using data from 1340 cognitively unimpaired participants between 18–94 years of age from multiple sites, we showed that topological properties of graphs constructed from rs-fMRI can predict chronological age across the lifespan. Application of our predictive model to the context of pre-clinical AD revealed that the pre-symptomatic phase of autosomal dominant AD includes acceleration of functional brain aging. This association was stronger in individuals having significant Aβ pathology.",

author = "\{Alzheimer{\textquoteright}s Disease Neuroimaging Initiative (ADNI)\} and \{Dominantly Inherited Alzheimer Network (DIAN) Study Group\} and \{Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer{\textquoteright}s Disease (PREVENT-AD) Research Group\} and Julie Gonneaud and Baria, \{Alex T.\} and \{Pichet Binette\}, Alexa and Gordon, \{Brian A.\} and Chhatwal, \{Jasmeer P.\} and Carlos Cruchaga and Mathias Jucker and Johannes Levin and Stephen Salloway and Martin Farlow and Serge Gauthier and Benzinger, \{Tammie L.S.\} and Morris, \{John C.\} and Bateman, \{Randall J.\} and Breitner, \{John C.S.\} and Judes Poirier and Etienne Vachon-Presseau and Sylvia Villeneuve and Michael Weiner and Rosen, \{Howard J.\} and Miller, \{Bruce L.\} and Paul Aisen and Thomas, \{Ronald G.\} and Michael Donohue and Sarah Walter and Devon Gessert and Tamie Sather and Gus Jiminez and Ronald Petersen and Jack, \{Clifford R.\} and Matthew Bernstein and Bret Borowski and Jeff Gunter and Matt Senjem and Prashanthi Vemuri and David Jones and Kejal Kantarci and Chad Ward and Mason, \{Sara S.\} and Albers, \{Colleen S.\} and David Knopman and Kris Johnson and William Jagust and Susan Landau and Trojanowki, \{John Q.\} and Toga, \{Arthur W.\} and Karen Crawford and Scott Neu and Laurel Beckett and Danielle Harvey",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = dec,

doi = "10.1038/s41467-021-25492-9",

language = "English (US)",

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Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dominantly Inherited Alzheimer Network (DIAN) Study Group & Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group 2021, 'Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease', Nature Communications, vol. 12, no. 1, 5346. https://doi.org/10.1038/s41467-021-25492-9

Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease. / Alzheimer’s Disease Neuroimaging Initiative (ADNI); Dominantly Inherited Alzheimer Network (DIAN) Study Group; Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group.
In: Nature Communications, Vol. 12, No. 1, 5346, 12.2021.

Research output: Contribution to journal › Article › peer-review

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T1 - Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

AU - Alzheimer’s Disease Neuroimaging Initiative (ADNI)

AU - Dominantly Inherited Alzheimer Network (DIAN) Study Group

AU - Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group

AU - Gonneaud, Julie

AU - Baria, Alex T.

AU - Pichet Binette, Alexa

AU - Gordon, Brian A.

AU - Chhatwal, Jasmeer P.

AU - Cruchaga, Carlos

AU - Jucker, Mathias

AU - Levin, Johannes

AU - Salloway, Stephen

AU - Farlow, Martin

AU - Gauthier, Serge

AU - Benzinger, Tammie L.S.

AU - Morris, John C.

AU - Bateman, Randall J.

AU - Breitner, John C.S.

AU - Poirier, Judes

AU - Vachon-Presseau, Etienne

AU - Villeneuve, Sylvia

AU - Weiner, Michael

AU - Rosen, Howard J.

AU - Miller, Bruce L.

AU - Aisen, Paul

AU - Thomas, Ronald G.

AU - Donohue, Michael

AU - Walter, Sarah

AU - Gessert, Devon

AU - Sather, Tamie

AU - Jiminez, Gus

AU - Petersen, Ronald

AU - Jack, Clifford R.

AU - Bernstein, Matthew

AU - Borowski, Bret

AU - Gunter, Jeff

AU - Senjem, Matt

AU - Vemuri, Prashanthi

AU - Jones, David

AU - Kantarci, Kejal

AU - Ward, Chad

AU - Mason, Sara S.

AU - Albers, Colleen S.

AU - Knopman, David

AU - Johnson, Kris

AU - Jagust, William

AU - Landau, Susan

AU - Trojanowki, John Q.

AU - Toga, Arthur W.

AU - Crawford, Karen

AU - Neu, Scott

AU - Beckett, Laurel

AU - Harvey, Danielle

PY - 2021/12

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AB - Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer’s disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD. We developed a model that predicts brain age from resting state (rs)-fMRI data, and assessed whether genetic determinants of AD, as well as beta-amyloid (Aβ) pathology, can accelerate brain aging. Using data from 1340 cognitively unimpaired participants between 18–94 years of age from multiple sites, we showed that topological properties of graphs constructed from rs-fMRI can predict chronological age across the lifespan. Application of our predictive model to the context of pre-clinical AD revealed that the pre-symptomatic phase of autosomal dominant AD includes acceleration of functional brain aging. This association was stronger in individuals having significant Aβ pathology.

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DO - 10.1038/s41467-021-25492-9

M3 - Article

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SN - 2041-1723

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Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dominantly Inherited Alzheimer Network (DIAN) Study Group, Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group. Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease. Nature Communications. 2021 Dec;12(1):5346. doi: 10.1038/s41467-021-25492-9

Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

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