Acquired aplastic anemia: Treatment in a developing country

Shaheena Hanif, Farah Naz, Emad Uddin Siddiqui, Jamal Raza

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Objective: The aim of this study was to evaluate the clinical presentation of aplastic anemia as well as to assess the efficacy of Cyclosporin -A in patients with aplastic anemia. Methodology: This is a hospital based interventional study. During the three year study period, 44 children were enrolled. Mean age was 9.3 years and there was a male predominance. Results: Most common clinical presentation was anemia and bleeding. Four children died before therapy was started. Cyclosporin-A was started in 40 patients. Eleven patients died before completion of therapy and three patients were lost to follow-up. Out of 26 patients who completed therapy, 11 were cured and 9 were responders while 6 were non responders according to the selected criteria. Conclusion: In developing third world countries like Pakistan majority of the patients with aplastic anemia cannot afford BMT. Alternative modalities of treatment must therefore be looked into. Cyclosporin-A seems to be a reasonable therapeutic option in such cases.

Original languageEnglish
Pages (from-to)370-374
Number of pages5
JournalPakistan Journal of Medical Sciences
Issue number3
Publication statusPublished - Apr 2007


  • Aplastic anemia
  • Cyclosporin-A
  • Immunosuppression


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