Acute myelofibrosis and multiple chloromas of the mandible and skin

Mansoor N. Saleh, Brad Rodu, Josef T. Prchal, Elias Romero De Leon

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Acute myelofibrosis is a rare clinical entity characterized by severe marrow fibrosis and peripheral blood pancytopenia. It may be very closely related to and has been considered synonymous with megakaryocytic leukemia. Chloroma is also a rare entity composed of a localized collection of immature myeloid cells and is associated with a known or covert leukemia. A patient presenting with a rare combination of acute myelofibrosis, megakaryocytic leukemia and multiple chloromas of the mandible and skin, are described. Although presenting a diagnostic challenge, their combination in one patient aids in the understanding of the myeloproliferative process. To our knowledge, this is the 3rd case of chloroma involving the oral osseous structures.

Original languageEnglish
Pages (from-to)108-111
Number of pages4
JournalInternational Journal of Oral and Maxillofacial Surgery
Issue number1
Publication statusPublished - Feb 1987
Externally publishedYes


  • chloroma
  • leukemia
  • mandible
  • myelofibrosis


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