Adherence to lipid monitoring and its impact on treat intensification of LDL-C lowering therapies at an urban academic medical center

Christine Tran, Victoria Vo, Perry Taylor, Deborah A. Koehn, Salim S. Virani, Dave L. Dixon

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background: Lipid monitoring is recommended by treatment guidelines to assess efficacy and adherence to lipid lowering therapy, but the available data is mostly limited to integrated health delivery systems with less diverse populations. Objective: To determine the proportion of patients that completed appropriate lipid monitoring at an urban academic medical center and whether lipid monitoring is associated with treatment intensification. Methods: Adults prescribed ≥1 LDL-C lowering therapy and with ≥1 outpatient encounter during 2018 and 2019 were included. Appropriate lipid monitoring was defined as ≥1 lipid panel obtained during the 12 month follow up period. Treatment intensification was defined as a dose increase, change to a higher intensity statin, or addition of a new LDL-C lowering therapy. The association between lipid monitoring and treatment intensification were assessed using regression models. Results: Of the 12,332 patients on LDL-C lowering therapy, 88% had ≥1 lipid panel. The average patient was 60 years of age, 50% were female, and 50% identified as black or African American. On regression analysis (odds ratio [OR], 95% confidence interval [CI]), lipid monitoring occurred less frequently in adults >75 years of age (0.63, 0.44 to 0.90), black or African American individuals (0.78, 0.69 to 0.89), and those insured by Medicaid (0.72, 0.61 to 0.86). The odds of treatment intensification steadily increased with the number of lipid panels compared to those without lipid monitoring. Conclusion: Lipid monitoring is associated with treatment intensification but occurs less frequently in adults >75 years of age, black or African American individuals, and those insured by Medicaid.

Original languageEnglish
Pages (from-to)491-497
Number of pages7
JournalJournal of Clinical Lipidology
Volume16
Issue number4
DOIs
Publication statusPublished - 1 Jul 2022
Externally publishedYes

Keywords

  • Atherosclerotic Cardiovascular disease
  • Guideline adherence
  • LDL cholesterol
  • Lipids

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