Aging: Generation of oxidative stress

Rehana Rehman; Ihsan Nazurah Zulkipli; Haq Nawaz Khan

doi:10.1016/B978-0-443-18807-7.00007-7

Aging: Generation of oxidative stress

Rehana Rehman, Ihsan Nazurah Zulkipli, Haq Nawaz Khan

Department of Biological & Biomedical Sciences, Medical College, Pakistan

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Oxidative stress (OS) is a physiological process occurring as a result of an imbalance of reactive oxygen species (ROS) production and the body's antioxidant defense system. ROS are highly reactive molecules that can harm DNA, proteins, and lipids in the body, leading to cellular damage and dysfunction. As we age, ROS production increases, which continues to accumulate with a decrease in the antioxidant defense system of the body. Aging is thus a multifaceted process that involves a gradual debility of various physiological functions, including the body's capability to manage OS. This condition can contribute to various “age-related diseases,” affecting the cardiovascular and nervous systems, as well as leading to the progression of cancer. This chapter will introduce aging, describe its causative factors, narrate theories, discuss manifestations in “age-related diseases,” and suggest ways to improve the redox potential.

Original language	English
Title of host publication	Fundamental Principles of Oxidative Stress in Metabolism and Reproduction
Subtitle of host publication	Prevention and Management
Publisher	Elsevier
Pages	105-119
Number of pages	15
ISBN (Electronic)	9780443188077
ISBN (Print)	9780443188060
DOIs	https://doi.org/10.1016/B978-0-443-18807-7.00007-7
Publication status	Published - 1 Jan 2024

Keywords

Age
Free radical theory
Oxidative stress
Reactive nitrogen species
Reactive oxygen species

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-443-18807-7.00007-7

Cite this

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title = "Aging: Generation of oxidative stress",

abstract = "Oxidative stress (OS) is a physiological process occurring as a result of an imbalance of reactive oxygen species (ROS) production and the body's antioxidant defense system. ROS are highly reactive molecules that can harm DNA, proteins, and lipids in the body, leading to cellular damage and dysfunction. As we age, ROS production increases, which continues to accumulate with a decrease in the antioxidant defense system of the body. Aging is thus a multifaceted process that involves a gradual debility of various physiological functions, including the body's capability to manage OS. This condition can contribute to various “age-related diseases,” affecting the cardiovascular and nervous systems, as well as leading to the progression of cancer. This chapter will introduce aging, describe its causative factors, narrate theories, discuss manifestations in “age-related diseases,” and suggest ways to improve the redox potential.",

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T1 - Aging

T2 - Generation of oxidative stress

AU - Rehman, Rehana

AU - Zulkipli, Ihsan Nazurah

AU - Khan, Haq Nawaz

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Y1 - 2024/1/1

N2 - Oxidative stress (OS) is a physiological process occurring as a result of an imbalance of reactive oxygen species (ROS) production and the body's antioxidant defense system. ROS are highly reactive molecules that can harm DNA, proteins, and lipids in the body, leading to cellular damage and dysfunction. As we age, ROS production increases, which continues to accumulate with a decrease in the antioxidant defense system of the body. Aging is thus a multifaceted process that involves a gradual debility of various physiological functions, including the body's capability to manage OS. This condition can contribute to various “age-related diseases,” affecting the cardiovascular and nervous systems, as well as leading to the progression of cancer. This chapter will introduce aging, describe its causative factors, narrate theories, discuss manifestations in “age-related diseases,” and suggest ways to improve the redox potential.

AB - Oxidative stress (OS) is a physiological process occurring as a result of an imbalance of reactive oxygen species (ROS) production and the body's antioxidant defense system. ROS are highly reactive molecules that can harm DNA, proteins, and lipids in the body, leading to cellular damage and dysfunction. As we age, ROS production increases, which continues to accumulate with a decrease in the antioxidant defense system of the body. Aging is thus a multifaceted process that involves a gradual debility of various physiological functions, including the body's capability to manage OS. This condition can contribute to various “age-related diseases,” affecting the cardiovascular and nervous systems, as well as leading to the progression of cancer. This chapter will introduce aging, describe its causative factors, narrate theories, discuss manifestations in “age-related diseases,” and suggest ways to improve the redox potential.

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KW - Free radical theory

KW - Oxidative stress

KW - Reactive nitrogen species

KW - Reactive oxygen species

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ER -

Aging: Generation of oxidative stress

Abstract

Keywords

UN SDGs

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