This study describes the bronchodilatory, vaso-relaxant and cardiac inhibitory effects of aqueous fractions of Olea europea (Oe.Aq) and Terminalia bellerica (Tb.Aq) fruits. In guinea-pig tracheal preparations, Oe.Aq and Tb.Aq caused concentration-dependent (0.03-5 mg/mL) relaxation of carbachol (CCh, 1 μM) and high potassium (80 mM)-induced contractions. When tested on rabbit aortic rings, against phenylephrine (PE, 1 μM) and potassium (K +)-induced contractions, Oe.Aq and Tb.Aq caused non-specific inhibition of the induced contractions. In isolated guinea-pig atria, Oe.Aq and Tb.Aq exhibited a suppressive effect on the atrial force and the rate of contractions. These data indicate that Olea europea and Terminalia bellerica aqueous fractions possess airways and cardiovascular inhibitory activities, via calcium antagonism like verapamil.
|Number of pages||6|
|Publication status||Published - 2010|
- Cardiac inhibitory effect
- Olea europea
- Terminalia bellerica