Alte und neue Gerinnungshemmer: Antidota und Manahmen bei akuter Blutung sowie dringenden Eingriffen

Translated title of the contribution: Old and new anticoagulants: Antidotes and measures for acute hemorrhaging and urgent interventions

M. Lancé, B. Stessel, K. Hamulyák, M. A. Marcus

Research output: Contribution to journalReview articlepeer-review

Abstract

Anticoagulation medications are frequently used for primary and secondary treatment of several thrombo-embolic disorders. An important side effect of all anticoagulants is hemorrhagic diathesis which necessitates acute treatment, ideally using medicinal therapy with an antidote. Much experience has been gained in treating bleeding while on traditional anticoagulants, such as heparins and vitamin K antagonists by the use of antagonists. A multitude of factor-specific anticoagulants have recently been introduced or will soon receive approval. With this new generation of anticoagulants no valid laboratory parameters or effective antagonists are presently available. Due to a lack of adequate studies regarding acute treatment this can at present only be carried out on a symptomatic basis.

Translated title of the contributionOld and new anticoagulants: Antidotes and measures for acute hemorrhaging and urgent interventions
Original languageGerman
Pages (from-to)62-68
Number of pages7
JournalDer Anaesthesist
Volume59
Issue number1
DOIs
Publication statusPublished - Jan 2010
Externally publishedYes

Keywords

  • Acute hemorrhage
  • Anticoagulation
  • Clinical treatment
  • Drug monitoring

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