Alteration of cyclic nucleotide levels in brain following intracranial self-stimulation in the rat

Eleftherios Miliaressis; Zulfiquar Merali

doi:10.1016/0091-3057(79)90305-8

Alteration of cyclic nucleotide levels in brain following intracranial self-stimulation in the rat

Eleftherios Miliaressis, Zulfiquar Merali

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

In a first experiment, 14 rats were implanted with an electrode in the ventral tegmental area and trained to self-stimulate. On the experimental day only half of the rats were allowed to self-stimulate for one hour. All rats were then sacrificed by immersion in liquid nitrogen. Seven brain regions were dissected and assayed for the endogenous concentration of cyclic nucleotides. Self-stimulation induced significant changes in striatum and hippocampus. However, a subsequent experiment showed that the same pattern of changes in the striatum can be produced by motor activity. On the other hand, changes in the hippocampus were specific to the self-stimulation group suggesting that this structure is associated with the brain reward system.

Original language	English
Pages (from-to)	107-110
Number of pages	4
Journal	Pharmacology Biochemistry and Behavior
Volume	11
Issue number	1
DOIs	https://doi.org/10.1016/0091-3057(79)90305-8
Publication status	Published - Jul 1979
Externally published	Yes

Keywords

Cyclic-nucleotides
Hippocampus
Motor activity
Self-stimulation
Striatum

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10.1016/0091-3057(79)90305-8

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title = "Alteration of cyclic nucleotide levels in brain following intracranial self-stimulation in the rat",

abstract = "In a first experiment, 14 rats were implanted with an electrode in the ventral tegmental area and trained to self-stimulate. On the experimental day only half of the rats were allowed to self-stimulate for one hour. All rats were then sacrificed by immersion in liquid nitrogen. Seven brain regions were dissected and assayed for the endogenous concentration of cyclic nucleotides. Self-stimulation induced significant changes in striatum and hippocampus. However, a subsequent experiment showed that the same pattern of changes in the striatum can be produced by motor activity. On the other hand, changes in the hippocampus were specific to the self-stimulation group suggesting that this structure is associated with the brain reward system.",

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AU - Miliaressis, Eleftherios

AU - Merali, Zulfiquar

N1 - Funding Information: 1Supported by a grant (A8625) to E. Miliaressis from the National Research Council of Canada.

PY - 1979/7

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N2 - In a first experiment, 14 rats were implanted with an electrode in the ventral tegmental area and trained to self-stimulate. On the experimental day only half of the rats were allowed to self-stimulate for one hour. All rats were then sacrificed by immersion in liquid nitrogen. Seven brain regions were dissected and assayed for the endogenous concentration of cyclic nucleotides. Self-stimulation induced significant changes in striatum and hippocampus. However, a subsequent experiment showed that the same pattern of changes in the striatum can be produced by motor activity. On the other hand, changes in the hippocampus were specific to the self-stimulation group suggesting that this structure is associated with the brain reward system.

AB - In a first experiment, 14 rats were implanted with an electrode in the ventral tegmental area and trained to self-stimulate. On the experimental day only half of the rats were allowed to self-stimulate for one hour. All rats were then sacrificed by immersion in liquid nitrogen. Seven brain regions were dissected and assayed for the endogenous concentration of cyclic nucleotides. Self-stimulation induced significant changes in striatum and hippocampus. However, a subsequent experiment showed that the same pattern of changes in the striatum can be produced by motor activity. On the other hand, changes in the hippocampus were specific to the self-stimulation group suggesting that this structure is associated with the brain reward system.

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Alteration of cyclic nucleotide levels in brain following intracranial self-stimulation in the rat

Abstract

Keywords

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