Alterations in striatal acetylcholine, acetylcholine esterase and dopamine after methadone replacement in morphine-dependent rats

Zulfiquar Merali; Prasanta K. Ghosh; Pavel D. Hrdina; Radhey L. Singhal; G. M. Ling

doi:10.1016/0014-2999(74)90249-0

Alterations in striatal acetylcholine, acetylcholine esterase and dopamine after methadone replacement in morphine-dependent rats

Zulfiquar Merali, Prasanta K. Ghosh, Pavel D. Hrdina, Radhey L. Singhal, G. M. Ling

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Chronic treatment of rats with morphine was found to produced a significant increase in endogenous ACh and DA as well as a decrease in AChE activity of rat striatum. Narcotic withdrawal for 48 hr resulted in a reversal of morphine-induced changes in striatal ACh levels and AChE activity whereas the enhanced striatal DA remained unaltered. Methadone replacement failed to affect the changes in striatal ACh and AChE activity but abolished the increases in striatal DA seen in morphine-withdrawn rats. Our results suggest that 'morphine addiction' in rats may involve alterations in the cholinergic and dopaminergic mechanisms of the striatum and that methadone replacement influences primarily the changes in the dopaminergic system produced by chronic morphine and its subsequent withdrawal.

Original language	English
Pages (from-to)	375-378
Number of pages	4
Journal	European Journal of Pharmacology
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(74)90249-0
Publication status	Published - May 1974
Externally published	Yes

Keywords

Acetylcholine
Chronic morphine
Dopamine
Methadone
Rat
Striatum
Withdrawal

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10.1016/0014-2999(74)90249-0

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title = "Alterations in striatal acetylcholine, acetylcholine esterase and dopamine after methadone replacement in morphine-dependent rats",

abstract = "Chronic treatment of rats with morphine was found to produced a significant increase in endogenous ACh and DA as well as a decrease in AChE activity of rat striatum. Narcotic withdrawal for 48 hr resulted in a reversal of morphine-induced changes in striatal ACh levels and AChE activity whereas the enhanced striatal DA remained unaltered. Methadone replacement failed to affect the changes in striatal ACh and AChE activity but abolished the increases in striatal DA seen in morphine-withdrawn rats. Our results suggest that 'morphine addiction' in rats may involve alterations in the cholinergic and dopaminergic mechanisms of the striatum and that methadone replacement influences primarily the changes in the dopaminergic system produced by chronic morphine and its subsequent withdrawal.",

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T1 - Alterations in striatal acetylcholine, acetylcholine esterase and dopamine after methadone replacement in morphine-dependent rats

AU - Merali, Zulfiquar

AU - Ghosh, Prasanta K.

AU - Hrdina, Pavel D.

AU - Singhal, Radhey L.

AU - Ling, G. M.

PY - 1974/5

Y1 - 1974/5

N2 - Chronic treatment of rats with morphine was found to produced a significant increase in endogenous ACh and DA as well as a decrease in AChE activity of rat striatum. Narcotic withdrawal for 48 hr resulted in a reversal of morphine-induced changes in striatal ACh levels and AChE activity whereas the enhanced striatal DA remained unaltered. Methadone replacement failed to affect the changes in striatal ACh and AChE activity but abolished the increases in striatal DA seen in morphine-withdrawn rats. Our results suggest that 'morphine addiction' in rats may involve alterations in the cholinergic and dopaminergic mechanisms of the striatum and that methadone replacement influences primarily the changes in the dopaminergic system produced by chronic morphine and its subsequent withdrawal.

AB - Chronic treatment of rats with morphine was found to produced a significant increase in endogenous ACh and DA as well as a decrease in AChE activity of rat striatum. Narcotic withdrawal for 48 hr resulted in a reversal of morphine-induced changes in striatal ACh levels and AChE activity whereas the enhanced striatal DA remained unaltered. Methadone replacement failed to affect the changes in striatal ACh and AChE activity but abolished the increases in striatal DA seen in morphine-withdrawn rats. Our results suggest that 'morphine addiction' in rats may involve alterations in the cholinergic and dopaminergic mechanisms of the striatum and that methadone replacement influences primarily the changes in the dopaminergic system produced by chronic morphine and its subsequent withdrawal.

KW - Acetylcholine

KW - Chronic morphine

KW - Dopamine

KW - Methadone

KW - Rat

KW - Striatum

KW - Withdrawal

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Alterations in striatal acetylcholine, acetylcholine esterase and dopamine after methadone replacement in morphine-dependent rats

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