Analysis of 114 pedigrees of renal stone patients: A retrospective review

Syed Raziuddin Biyabani; Jamsheer Jehangir Talati; Daniya Umer; Zehra Kazmi; Hussam Uddin Soomro; Rubab Mansoor

Analysis of 114 pedigrees of renal stone patients: A retrospective review

Syed Raziuddin Biyabani, Jamsheer Jehangir Talati, Daniya Umer, Zehra Kazmi, Hussam Uddin Soomro, Rubab Mansoor

Section of Urology, Department of Surgery, Medical College, Pakistan

Research output: Contribution to journal › Article

Abstract

Background: Renal and ureteric stones (RS) can form due to genetic, metabolic, environmental, and diet-hydration related factors. Studies have shown that patients with family history (FH) of RS have higher likelihood of recurrence.Materials and methods: We conducted a retrospective cross-sectional study on 114 pedigrees to investigate the impact of FH on recurrence of RS and examine patterns of inheritance. Results: Family history of renal stone disease was found in 42% of all patients. There was a significant increase of stone recurrence in RS patients with a positive FH (p=0.001). Seventy-one percent of patients with recurrent stones had at least one family member with RS. Interestingly, male penetrance was higher in RS recurrence, where a greater proportion of males had no FH of RS, indicating that there may be other factors involved as well. Conclusion: Family history in RS patients should be continuously explored for the possible underlying genetic influence, whilst keeping in mind the dietary habits of the family.

Original language	Undefined/Unknown
Journal	Section of Urology
Publication status	Published - 21 Feb 2021

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Analysis of 114 pedigrees of renal stone patients: A retrospectiv

http://ecommons.aku.edu/pakistan_fhs_mc_surg_urol/175

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title = "Analysis of 114 pedigrees of renal stone patients: A retrospective review",

abstract = "Background: Renal and ureteric stones (RS) can form due to genetic, metabolic, environmental, and diet-hydration related factors. Studies have shown that patients with family history (FH) of RS have higher likelihood of recurrence.Materials and methods: We conducted a retrospective cross-sectional study on 114 pedigrees to investigate the impact of FH on recurrence of RS and examine patterns of inheritance. Results: Family history of renal stone disease was found in 42% of all patients. There was a significant increase of stone recurrence in RS patients with a positive FH (p=0.001). Seventy-one percent of patients with recurrent stones had at least one family member with RS. Interestingly, male penetrance was higher in RS recurrence, where a greater proportion of males had no FH of RS, indicating that there may be other factors involved as well. Conclusion: Family history in RS patients should be continuously explored for the possible underlying genetic influence, whilst keeping in mind the dietary habits of the family.",

author = "Biyabani, {Syed Raziuddin} and Talati, {Jamsheer Jehangir} and Daniya Umer and Zehra Kazmi and Soomro, {Hussam Uddin} and Rubab Mansoor",

year = "2021",

month = feb,

day = "21",

language = "Undefined/Unknown",

journal = "Section of Urology",

}

TY - JOUR

T1 - Analysis of 114 pedigrees of renal stone patients: A retrospective review

AU - Biyabani, Syed Raziuddin

AU - Talati, Jamsheer Jehangir

AU - Umer, Daniya

AU - Kazmi, Zehra

AU - Soomro, Hussam Uddin

AU - Mansoor, Rubab

PY - 2021/2/21

Y1 - 2021/2/21

N2 - Background: Renal and ureteric stones (RS) can form due to genetic, metabolic, environmental, and diet-hydration related factors. Studies have shown that patients with family history (FH) of RS have higher likelihood of recurrence.Materials and methods: We conducted a retrospective cross-sectional study on 114 pedigrees to investigate the impact of FH on recurrence of RS and examine patterns of inheritance. Results: Family history of renal stone disease was found in 42% of all patients. There was a significant increase of stone recurrence in RS patients with a positive FH (p=0.001). Seventy-one percent of patients with recurrent stones had at least one family member with RS. Interestingly, male penetrance was higher in RS recurrence, where a greater proportion of males had no FH of RS, indicating that there may be other factors involved as well. Conclusion: Family history in RS patients should be continuously explored for the possible underlying genetic influence, whilst keeping in mind the dietary habits of the family.

AB - Background: Renal and ureteric stones (RS) can form due to genetic, metabolic, environmental, and diet-hydration related factors. Studies have shown that patients with family history (FH) of RS have higher likelihood of recurrence.Materials and methods: We conducted a retrospective cross-sectional study on 114 pedigrees to investigate the impact of FH on recurrence of RS and examine patterns of inheritance. Results: Family history of renal stone disease was found in 42% of all patients. There was a significant increase of stone recurrence in RS patients with a positive FH (p=0.001). Seventy-one percent of patients with recurrent stones had at least one family member with RS. Interestingly, male penetrance was higher in RS recurrence, where a greater proportion of males had no FH of RS, indicating that there may be other factors involved as well. Conclusion: Family history in RS patients should be continuously explored for the possible underlying genetic influence, whilst keeping in mind the dietary habits of the family.

M3 - Article

JO - Section of Urology

JF - Section of Urology

ER -