Anatomy and embryology of abdominal wall defects

Faraz A. Khan, Steven L. Raymond, Asra Hashmi, Saleem Islam

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Abdominal wall defects are one of the most frequently encountered human congenital anomalies. They are seen in as many as 1 in 2,000 live births with evidence to suggest that their incidence is increasing. While often discussed together abdominal wall defects consist mainly of two entities namely gastroschisis and omphalocele. There are marked differences in their theories of embryo-pathogenesis, clinical presentation/anatomy and overall outcomes. There is no clear consensus explaining the precise embryological mechanisms leading to the development of abdominal wall defects. Many clinicians and embryologists have attempted to explain the genesis of congenital abdominal wall defects because of failure of progression of various phases of normal embryonic development. This review summarizes the mechanisms involved in normal and abnormal development of the ventral abdominal wall leading to the development of gastroschisis and omphalocele.

Original languageEnglish
Article number151230
JournalSeminars in Pediatric Surgery
Issue number6
Publication statusPublished - Dec 2022
Externally publishedYes


  • Abdominal Wall Development
  • Congenital Abdominal Wall Defect
  • Gastroschisis
  • Omphalocele


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