Anti-hormonal therapy serves as a possible treatment modality for intracranial meningiomas

Meningiomas are benign, slow growing, hormonesensitive primary brain tumours. Surgical resection is usually the definitive treatment although management of recurrent or difficult to resect meningiomas poses a challenge to neurosurgeons. Efficacy of medical therapy for meningioma has been studied widely and several retrospective and case control studies have shown contradicting results, some supporting the strong relation between increased production of reproductive hormones and tumour growth; and others not reporting any association. Randomized controlled trials (RCTs) have also not reported any statistically significant improvement while using anti-hormonal treatment for recurrent meningiomas. It is important to understand how endogenous or exogenous hormones affect tumour growth so that exact mechanism can be targeted through medical therapy.