Anti NMDA receptor antibody encephalitis in Pakistan: Clinicopathological features and treatment outcomes

Shafain Sheikh, Arsalan Ahmad, Tahir Aziz Ahmed

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Anti-NMDA receptor antibody encephalitis (anti-NMDAR Encephalitis) is the most common subtype of autoimmune encephalitis in which IgG antibodies directed against NR1 subunit of NMDA receptors are present. It is a potentially lethal encephalitis which responds favourably to timely immunosuppressive therapy. If untreated, its progression leads from delusions, paranoia, movement disorder, memory deficit and seizures into a state of unresponsiveness with autonomic instability and even death. We present clinicopathological features, treatment and outcomes of eight autoantibodyproven cases of anti-NMDAR Encephalitis. There were 7 females and 1 male with a mean age of 15 years (age range: 1 to 28 years). Clinical features included seizures, altered consciousness, memory deficit, delusions, paranoia and hallucinations. Hyperactivity and irritability were prominent features among the children. Patients treated with immunosuppressive therapy including steroids, IVIg, plasmapheresis and Rituximab, recovered completely within a month of therapy. Whereas patients who received only steroids as immunosuppressive therapy suffered from residual brain damage.

Original languageEnglish
Pages (from-to)1910-1914
Number of pages5
JournalJPMA. The Journal of the Pakistan Medical Association
Volume69
Issue number12
DOIs
Publication statusPublished - 1 Dec 2019
Externally publishedYes

Keywords

  • Anti-NMDAR Encephalitis, Immunosuppressive therapy, plasmapheresis, IVIG

Fingerprint

Dive into the research topics of 'Anti NMDA receptor antibody encephalitis in Pakistan: Clinicopathological features and treatment outcomes'. Together they form a unique fingerprint.

Cite this