TY - JOUR
T1 - Antibacterial, antifungal, antispasmodic and Ca ++ antagonist effects of Caesalpinia bonducella
AU - Khan, Hidayat Ullah
AU - Ali, Irshad
AU - Khan, Arif Ullah
AU - Naz, Rubina
AU - Gilani, Anwarul Hassan
PY - 2011/2
Y1 - 2011/2
N2 - Caesalpinia bonducella F. (Leguminosae) has been used as a folk medicine for a variety of ailments. The crude extract of C. bonducella and its fractions were studied for antibacterial, antifungal, antispasmodic and Ca ++ antagonistic properties. The strongest antibacterial effect was displayed by the n-butanol (72%) and ethyl acetate (80%) fractions, followed by the crude extract (46% and 42%), against Escherichia coli and Bacillus subtilis, respectively. The plant extract and its fractions showed mild to excellent activity in antifungal bioassays, with maximum antifungal activity against Candida glaberata (80%) and Aspergillus flavus (70%) by the n-butanol and chloroform fractions, followed by the crude extract (70% and 65%). Caesalpinia bonducella extract caused concentration-dependent inhibition of spontaneous and high K + (80 mM)-induced contractions of isolated rabbit jejunum preparations, similar to that caused by Verapamil. These results indicate that C. bonducella exhibits antibacterial, antifungal, spasmolytic and Ca ++ channel blocking actions.
AB - Caesalpinia bonducella F. (Leguminosae) has been used as a folk medicine for a variety of ailments. The crude extract of C. bonducella and its fractions were studied for antibacterial, antifungal, antispasmodic and Ca ++ antagonistic properties. The strongest antibacterial effect was displayed by the n-butanol (72%) and ethyl acetate (80%) fractions, followed by the crude extract (46% and 42%), against Escherichia coli and Bacillus subtilis, respectively. The plant extract and its fractions showed mild to excellent activity in antifungal bioassays, with maximum antifungal activity against Candida glaberata (80%) and Aspergillus flavus (70%) by the n-butanol and chloroform fractions, followed by the crude extract (70% and 65%). Caesalpinia bonducella extract caused concentration-dependent inhibition of spontaneous and high K + (80 mM)-induced contractions of isolated rabbit jejunum preparations, similar to that caused by Verapamil. These results indicate that C. bonducella exhibits antibacterial, antifungal, spasmolytic and Ca ++ channel blocking actions.
KW - Ca antagonist
KW - Caesalpinia bonducella
KW - antimicrobial
KW - antispasmodic
UR - http://www.scopus.com/inward/record.url?scp=79951747238&partnerID=8YFLogxK
U2 - 10.1080/14786419.2010.529445
DO - 10.1080/14786419.2010.529445
M3 - Article
C2 - 21328138
AN - SCOPUS:79951747238
SN - 1478-6419
VL - 25
SP - 444
EP - 449
JO - Natural Product Research
JF - Natural Product Research
IS - 4
ER -