Antibacterial, antifungal, antispasmodic and Ca ++ antagonist effects of Caesalpinia bonducella

Hidayat Ullah Khan, Irshad Ali, Arif Ullah Khan, Rubina Naz, Anwarul Hassan Gilani

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Caesalpinia bonducella F. (Leguminosae) has been used as a folk medicine for a variety of ailments. The crude extract of C. bonducella and its fractions were studied for antibacterial, antifungal, antispasmodic and Ca ++ antagonistic properties. The strongest antibacterial effect was displayed by the n-butanol (72%) and ethyl acetate (80%) fractions, followed by the crude extract (46% and 42%), against Escherichia coli and Bacillus subtilis, respectively. The plant extract and its fractions showed mild to excellent activity in antifungal bioassays, with maximum antifungal activity against Candida glaberata (80%) and Aspergillus flavus (70%) by the n-butanol and chloroform fractions, followed by the crude extract (70% and 65%). Caesalpinia bonducella extract caused concentration-dependent inhibition of spontaneous and high K + (80 mM)-induced contractions of isolated rabbit jejunum preparations, similar to that caused by Verapamil. These results indicate that C. bonducella exhibits antibacterial, antifungal, spasmolytic and Ca ++ channel blocking actions.

Original languageEnglish
Pages (from-to)444-449
Number of pages6
JournalNatural Product Research
Volume25
Issue number4
DOIs
Publication statusPublished - Feb 2011
Externally publishedYes

Keywords

  • Ca antagonist
  • Caesalpinia bonducella
  • antimicrobial
  • antispasmodic

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