Abstract
Caesalpinia bonducella F. (Leguminosae) has been used as a folk medicine for a variety of ailments. The crude extract of C. bonducella and its fractions were studied for antibacterial, antifungal, antispasmodic and Ca ++ antagonistic properties. The strongest antibacterial effect was displayed by the n-butanol (72%) and ethyl acetate (80%) fractions, followed by the crude extract (46% and 42%), against Escherichia coli and Bacillus subtilis, respectively. The plant extract and its fractions showed mild to excellent activity in antifungal bioassays, with maximum antifungal activity against Candida glaberata (80%) and Aspergillus flavus (70%) by the n-butanol and chloroform fractions, followed by the crude extract (70% and 65%). Caesalpinia bonducella extract caused concentration-dependent inhibition of spontaneous and high K + (80 mM)-induced contractions of isolated rabbit jejunum preparations, similar to that caused by Verapamil. These results indicate that C. bonducella exhibits antibacterial, antifungal, spasmolytic and Ca ++ channel blocking actions.
| Original language | English (UK) |
|---|---|
| Pages (from-to) | 444-449 |
| Number of pages | 6 |
| Journal | Natural Product Research |
| Volume | 25 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Feb 2011 |
| Externally published | Yes |
Keywords
- Ca antagonist
- Caesalpinia bonducella
- antimicrobial
- antispasmodic