Antidiarrheal, antisecretory, and bronchodilatory activities of Hypericum perforatum

Arif Ullah Khan; Anwarul Hassan Gilani

doi:10.1080/13880200902960206

Antidiarrheal, antisecretory, and bronchodilatory activities of Hypericum perforatum

Arif Ullah Khan, Anwarul Hassan Gilani

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

This study describes the antidiarrheal, antisecretory, and bronchodilatory activities of Hypericum perforatum Linn. (Hypericaceae), commonly known as St. John's wort, to justify its traditional use in the hyperactivity of the gastrointestinal and respiratory systems. The crude extract of Hypericum perforatum (Hp.Cr) at a dose of 500mg/kg caused 20% protection against castor oil-induced diarrhea in mice and 60% at 1000mg/kg (p<0.05 vs. saline). Hp.Cr at 300 and 1000mg/kg reduced the castor oil-induced fluid accumulation in mice to 107.0±3.3g (p<0.01) and 84.0±4.2g (p<0.001) respectively, whereas in the castor oil-treated group, it was 126.9±3.9g. When tested against carbachol (CCh)-mediated bronchoconstriction in rats under anesthesia, Hp.Cr dose-dependently (3-30mg/kg) suppressed the CCh (1μmol/kg)-induced increase in the inspiratory pressure. Thus this study rationalizes the Hypericum perforatum usefulness in overactive gut and airways disorders, such as diarrhea and asthma.

Original language	English
Pages (from-to)	962-967
Number of pages	6
Journal	Pharmaceutical Biology
Volume	47
Issue number	10
DOIs	https://doi.org/10.1080/13880200902960206
Publication status	Published - Oct 2009
Externally published	Yes

Keywords

Antidiarrheal
Antisecretory
Bronchodilatory
Hypericum perforatum
In vivo
St. John's wort

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Antidiarrheal, antisecretory, and bronchodilatory activities of Hypericum perforatum",

abstract = "This study describes the antidiarrheal, antisecretory, and bronchodilatory activities of Hypericum perforatum Linn. (Hypericaceae), commonly known as St. John's wort, to justify its traditional use in the hyperactivity of the gastrointestinal and respiratory systems. The crude extract of Hypericum perforatum (Hp.Cr) at a dose of 500mg/kg caused 20% protection against castor oil-induced diarrhea in mice and 60% at 1000mg/kg (p<0.05 vs. saline). Hp.Cr at 300 and 1000mg/kg reduced the castor oil-induced fluid accumulation in mice to 107.0±3.3g (p<0.01) and 84.0±4.2g (p<0.001) respectively, whereas in the castor oil-treated group, it was 126.9±3.9g. When tested against carbachol (CCh)-mediated bronchoconstriction in rats under anesthesia, Hp.Cr dose-dependently (3-30mg/kg) suppressed the CCh (1μmol/kg)-induced increase in the inspiratory pressure. Thus this study rationalizes the Hypericum perforatum usefulness in overactive gut and airways disorders, such as diarrhea and asthma.",

keywords = "Antidiarrheal, Antisecretory, Bronchodilatory, Hypericum perforatum, In vivo, St. John's wort",

author = "Khan, {Arif Ullah} and Gilani, {Anwarul Hassan}",

note = "Funding Information: Declaration of interest: This study was supported by funds made available by the Pakistan Science Foundation and Higher Education Commission, Government of Pakistan.",

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AU - Gilani, Anwarul Hassan

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N2 - This study describes the antidiarrheal, antisecretory, and bronchodilatory activities of Hypericum perforatum Linn. (Hypericaceae), commonly known as St. John's wort, to justify its traditional use in the hyperactivity of the gastrointestinal and respiratory systems. The crude extract of Hypericum perforatum (Hp.Cr) at a dose of 500mg/kg caused 20% protection against castor oil-induced diarrhea in mice and 60% at 1000mg/kg (p<0.05 vs. saline). Hp.Cr at 300 and 1000mg/kg reduced the castor oil-induced fluid accumulation in mice to 107.0±3.3g (p<0.01) and 84.0±4.2g (p<0.001) respectively, whereas in the castor oil-treated group, it was 126.9±3.9g. When tested against carbachol (CCh)-mediated bronchoconstriction in rats under anesthesia, Hp.Cr dose-dependently (3-30mg/kg) suppressed the CCh (1μmol/kg)-induced increase in the inspiratory pressure. Thus this study rationalizes the Hypericum perforatum usefulness in overactive gut and airways disorders, such as diarrhea and asthma.

AB - This study describes the antidiarrheal, antisecretory, and bronchodilatory activities of Hypericum perforatum Linn. (Hypericaceae), commonly known as St. John's wort, to justify its traditional use in the hyperactivity of the gastrointestinal and respiratory systems. The crude extract of Hypericum perforatum (Hp.Cr) at a dose of 500mg/kg caused 20% protection against castor oil-induced diarrhea in mice and 60% at 1000mg/kg (p<0.05 vs. saline). Hp.Cr at 300 and 1000mg/kg reduced the castor oil-induced fluid accumulation in mice to 107.0±3.3g (p<0.01) and 84.0±4.2g (p<0.001) respectively, whereas in the castor oil-treated group, it was 126.9±3.9g. When tested against carbachol (CCh)-mediated bronchoconstriction in rats under anesthesia, Hp.Cr dose-dependently (3-30mg/kg) suppressed the CCh (1μmol/kg)-induced increase in the inspiratory pressure. Thus this study rationalizes the Hypericum perforatum usefulness in overactive gut and airways disorders, such as diarrhea and asthma.

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KW - Antisecretory

KW - Bronchodilatory

KW - Hypericum perforatum

KW - In vivo

KW - St. John's wort

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DO - 10.1080/13880200902960206

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Antidiarrheal, antisecretory, and bronchodilatory activities of Hypericum perforatum

Abstract

Keywords

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