Antidiarrhoeal and bronchodilatory potential of Valeriana wallichii

Arif Ullah Khan, Anwarul Hassan Gilani

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

This study describes the antidiarrhoeal and bronchodilatory activities of Valeriana wallichii D.C. (Valerianaceae). The crude extract of V. wallichii (Vw.Cr) caused inhibition of castor oil-induced diarrhoea in mice at 300-600 mg kg -1. In guinea-pig trachea, Vw.Cr concentration dependently (0.03-3.0 mg mL -1) relaxed the low K + (25 mM)-induced contractions, with a mild effect on the contractions induced by high K + (80 mM). In the presence of glibenclamide, the relaxation of low K +-induced contractions was prevented. Similarly, cromakalim caused glibenclamide-sensitive inhibition of low K +, without any effect on high K +. These results indicate that V. wallichii exhibits antidiarrhoeal and bronchodilatory activities, possibly through K + channel activation, and thus reveal its medicinal usefulness in hyperactive gut and airway disorders such as diarrhoea and asthma.

Original languageEnglish
Pages (from-to)1045-1049
Number of pages5
JournalNatural Product Research
Volume26
Issue number11
DOIs
Publication statusPublished - 1 Jun 2012
Externally publishedYes

Keywords

  • Antidiarrhoeal
  • Bronchodilator
  • Valeriana wallichii

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