Abstract
Objective: To measure the in-vitro activity of various antibiotics including tigecycline against Gram negative and positive nosocomial aerobic isolates. Methods: A total of 430 clinical isolates of both Gram positive (143) and negative (287) aerobic bacteria were used from 3 centres during the year 2006 and 2007. Minimum inhibitory concentration (MIC) was determined using broth micro dilution panels. Antibiotic resistance was interpreted using CLSI guidelines. Results: Most of the isolates were resistant to more than one drug. Resistance to tigecycline was not found. Tigecycline (1ug/ml) had low MIC against organisms tested. Conclusion: This data indicates that tigecycline, a new drug in its class, has broad-spectrum in-vitro activity against both Gram negative and positive nosocomial isolates. Therefore, it may be a suitable drug to be used for the treatment of highly resistant nosocomial infections.
| Original language | English |
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| Pages (from-to) | 240-242 |
| Number of pages | 3 |
| Journal | Journal of the Pakistan Medical Association |
| Volume | 59 |
| Issue number | 4 |
| Publication status | Published - Apr 2009 |