Antispasmodic, bronchodilator and blood pressure lowering properties of Hypericum oblongifolium - Possible mechanism of action

Arif Ullah Khan; Munasib Khan; Fazal Subhan; Anwarul Hassan Gilani

doi:10.1002/ptr.3067

Antispasmodic, bronchodilator and blood pressure lowering properties of Hypericum oblongifolium - Possible mechanism of action

Arif Ullah Khan, Munasib Khan, Fazal Subhan, Anwarul Hassan Gilani

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The crude extract of Hypericum oblongifolium (Ho.Cr), which tested positive for flavonoids, saponins and tannins caused concentration-dependent (0.1-1.0 mg/mL) relaxation of spontaneous and high K⁺ (80 mM)-induced contractions in isolated rabbit jejunum preparations, suggesting a Ca ⁺⁺ antagonistic effect, which was confirmed when pretreatment of the tissue with Ho.Cr produced a rightward shift in the Ca⁺⁺ concentration-response curves, like that caused by verapamil. Ho.Cr relaxed carbachol (1 μM) and high K⁺-induced contractions in guinea pig tracheal preparations. It caused a dose-dependent (3-100 mg/kg) fall in arterial blood pressure of rats under anesthesia. In isolated guinea pig atria, Ho.Cr caused inhibition of both atrial force and rate of spontaneous contractions. When tested in rabbit aortic rings, Ho.Cr exhibited a vasodilator effect against phenylephrine (1 μM) and high K⁺-induced contractions. These results indicate that Ho.Cr possesses gastrointestinal, respiratory and cardiovascular inhibitory effects, mediated via a Ca⁺⁺ antagonist mechanism.

Original language	English
Pages (from-to)	1027-1032
Number of pages	6
Journal	Phytotherapy Research
Volume	24
Issue number	7
DOIs	https://doi.org/10.1002/ptr.3067
Publication status	Published - Jul 2010
Externally published	Yes

Keywords

Antihypertensive
Antispasmodic
Bronchodilator
Ca antagonist
Hypericum oblongifolium

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10.1002/ptr.3067

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title = "Antispasmodic, bronchodilator and blood pressure lowering properties of Hypericum oblongifolium - Possible mechanism of action",

abstract = "The crude extract of Hypericum oblongifolium (Ho.Cr), which tested positive for flavonoids, saponins and tannins caused concentration-dependent (0.1-1.0 mg/mL) relaxation of spontaneous and high K+ (80 mM)-induced contractions in isolated rabbit jejunum preparations, suggesting a Ca ++ antagonistic effect, which was confirmed when pretreatment of the tissue with Ho.Cr produced a rightward shift in the Ca++ concentration-response curves, like that caused by verapamil. Ho.Cr relaxed carbachol (1 μM) and high K+-induced contractions in guinea pig tracheal preparations. It caused a dose-dependent (3-100 mg/kg) fall in arterial blood pressure of rats under anesthesia. In isolated guinea pig atria, Ho.Cr caused inhibition of both atrial force and rate of spontaneous contractions. When tested in rabbit aortic rings, Ho.Cr exhibited a vasodilator effect against phenylephrine (1 μM) and high K+-induced contractions. These results indicate that Ho.Cr possesses gastrointestinal, respiratory and cardiovascular inhibitory effects, mediated via a Ca++ antagonist mechanism.",

keywords = "Antihypertensive, Antispasmodic, Bronchodilator, Ca antagonist, Hypericum oblongifolium",

author = "Khan, {Arif Ullah} and Munasib Khan and Fazal Subhan and Gilani, {Anwarul Hassan}",

year = "2010",

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AU - Khan, Arif Ullah

AU - Khan, Munasib

AU - Subhan, Fazal

AU - Gilani, Anwarul Hassan

PY - 2010/7

Y1 - 2010/7

N2 - The crude extract of Hypericum oblongifolium (Ho.Cr), which tested positive for flavonoids, saponins and tannins caused concentration-dependent (0.1-1.0 mg/mL) relaxation of spontaneous and high K+ (80 mM)-induced contractions in isolated rabbit jejunum preparations, suggesting a Ca ++ antagonistic effect, which was confirmed when pretreatment of the tissue with Ho.Cr produced a rightward shift in the Ca++ concentration-response curves, like that caused by verapamil. Ho.Cr relaxed carbachol (1 μM) and high K+-induced contractions in guinea pig tracheal preparations. It caused a dose-dependent (3-100 mg/kg) fall in arterial blood pressure of rats under anesthesia. In isolated guinea pig atria, Ho.Cr caused inhibition of both atrial force and rate of spontaneous contractions. When tested in rabbit aortic rings, Ho.Cr exhibited a vasodilator effect against phenylephrine (1 μM) and high K+-induced contractions. These results indicate that Ho.Cr possesses gastrointestinal, respiratory and cardiovascular inhibitory effects, mediated via a Ca++ antagonist mechanism.

AB - The crude extract of Hypericum oblongifolium (Ho.Cr), which tested positive for flavonoids, saponins and tannins caused concentration-dependent (0.1-1.0 mg/mL) relaxation of spontaneous and high K+ (80 mM)-induced contractions in isolated rabbit jejunum preparations, suggesting a Ca ++ antagonistic effect, which was confirmed when pretreatment of the tissue with Ho.Cr produced a rightward shift in the Ca++ concentration-response curves, like that caused by verapamil. Ho.Cr relaxed carbachol (1 μM) and high K+-induced contractions in guinea pig tracheal preparations. It caused a dose-dependent (3-100 mg/kg) fall in arterial blood pressure of rats under anesthesia. In isolated guinea pig atria, Ho.Cr caused inhibition of both atrial force and rate of spontaneous contractions. When tested in rabbit aortic rings, Ho.Cr exhibited a vasodilator effect against phenylephrine (1 μM) and high K+-induced contractions. These results indicate that Ho.Cr possesses gastrointestinal, respiratory and cardiovascular inhibitory effects, mediated via a Ca++ antagonist mechanism.

KW - Antihypertensive

KW - Antispasmodic

KW - Bronchodilator

KW - Ca antagonist

KW - Hypericum oblongifolium

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JO - Phytotherapy Research

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IS - 7

ER -

Antispasmodic, bronchodilator and blood pressure lowering properties of Hypericum oblongifolium - Possible mechanism of action

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