Asian-Pacific consensus statement on the management of chronic hepatitis B: A 2012 update

Yun Fan Liaw, Jia Horng Kao, Teerha Piratvisuth, Henry Lik Yuen Chan, Rong Nan Chien, Chun Jen Liu, Ed Gane, Stephen Locarnini, Seng Gee Lim, Kwang Hyub Han, Deepak Amarapurkar, Graham Cooksley, Wasim Jafri, Rosmawati Mohamed, Jin Lin Hou, Wan Long Chuang, Laurentius A. Lesmana, Jose D. Sollano, Dong Jin Suh, Masao Omata

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853 Citations (Scopus)


Large volume of new data on the natural history and treatment of chronic hepatitis B virus (HBV) infection have become available since 2008. These include further studies in asymptomatic subjects with chronic HBV infection and community-based cohorts, the role of HBV genotype/naturally occurring HBV mutations, the application of non-invasive assessment of hepatic fibrosis and quantitation of HBV surface antigen and new drug or new strategies towards more effective therapy. To update HBV management guidelines, relevant new data were reviewed and assessed by experts from the region, and the significance of the reported findings was discussed and debated. The earlier "Asian-Pacific consensus statement on the management of chronic hepatitis B" was revised accordingly. The key terms used in the statement were also defined. The new guidelines include general management, indications for fibrosis assessment, time to start or stop drug therapy, choice of drug to initiate therapy, when and how to monitor the patients during and after stopping drug therapy. Recommendations on the therapy of patients in special circumstances, including women in childbearing age, patients with antiviral drug resistance, concurrent viral infection, hepatic decompensation, patients receiving immune suppression or chemotherapy and patients in the setting of liver transplantation and hepatocellular carcinoma, are also included.

Original languageEnglish
Pages (from-to)531-561
Number of pages31
JournalHepatology International
Issue number3
Publication statusPublished - Jun 2012


  • Adefovir
  • Chronic hepatitis B
  • Entecavir
  • Hepatitis B virus (HBV)
  • Hepatocellular carcinoma
  • Interferon-a
  • Lamivudine
  • Liver cirrhosis
  • Pegylated interferon
  • Telbivudine
  • Tenofovir


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