TY - JOUR
T1 - Assembling a global database of child pneumonia studies to inform WHO pneumonia management algorithm
T2 - Methodology and applications
AU - Martin, Helena
AU - Falconer, Jennifer
AU - Addo-Yobo, Emmanuel
AU - Aneja, Satinder
AU - Arroyo, Luis Martinez
AU - Asghar, Rai
AU - Awasthi, Shally
AU - Banajeh, Salem
AU - Bari, Abdul
AU - Basnet, Sudha
AU - Bavdekar, Ashish
AU - Bhandari, Nita
AU - Bhatnagar, Shinjini
AU - Bhutta, Zulfiqar A.
AU - Brooks, Abdullah
AU - Chadha, Mandeep
AU - Chisaka, Noel
AU - Chou, Monidarin
AU - Clara, Alexey W.
AU - Colbourn, Tim
AU - Cutland, Clare
AU - D’Acremont, Valérie
AU - Echavarria, Marcela
AU - Gentile, Angela
AU - Gessner, Brad
AU - Gregory, Christopher J.
AU - Hazir, Tabish
AU - Hibberd, Patricia L.
AU - Hirve, Siddhivinayak
AU - Hooli, Shubhada
AU - Iqbal, Imran
AU - Jeena, Prakash
AU - Kartasasmita, Cissy B.
AU - King, Carina
AU - Libster, Romina
AU - Lodha, Rakesh
AU - Lozano, Juan M.
AU - Lucero, Marilla
AU - Lufesi, Norman
AU - MacLeod, William B.
AU - Madhi, Shabir Ahmed
AU - Mathew, Joseph L.
AU - Maulen-Radovan, Irene
AU - McCollum, Eric D.
AU - Mino, Greta
AU - Mwansambo, Charles
AU - Neuman, Mark I.
AU - Nguyen, Ngoc Tuong Vy
AU - Nunes, Marta C.
AU - Nymadawa, Pagbajabyn
AU - O’Grady, Kerry Ann F.
AU - Pape, Jean William
AU - Paranhos-Baccala, Glaucia
AU - Patel, Archana
AU - Picot, Valentina Sanchez
AU - Rakoto-Andrianarivelo, Mala
AU - Rasmussen, Zeba
AU - Rouzier, Vanessa
AU - Russomando, Graciela
AU - Ruvinsky, Raul O.
AU - Sadruddin, Salim
AU - Saha, Samir K.
AU - Santosham, Mathuram
AU - Singhi, Sunit
AU - Soofi, Sajid
AU - Strand, Tor A.
AU - Sylla, Mariam
AU - Thamthitiwat, Somsak
AU - Thea, Donald M.
AU - Turner, Claudia
AU - Vanhems, Philippe
AU - Wadhwa, Nitya
AU - Wang, Jianwei
AU - Zaman, Syed M.A.
AU - Campbell, Harry
AU - Nair, Harish
AU - Qazi, Shamim Ahmad
AU - Nisar, Yasir Bin
N1 - Funding Information:
Disclaimer: YBN is an employee of the World Health Organization. The expressed views and opinions do not necessarily represent the policies of the World Health Organization. Ethics statement: All studies included in the PREPARE dataset were previously granted clearance by ethical review boards from each participating site. Included studies which were sponsored by the World Health Organization additionally received ethical approval from the World Health Organization ethics review committee. Data availability: Data may be made available upon reasonable request to the corresponding author. Funding: This study was funded by the Bill & Melinda Gates Foundation (#INV-007927) through a grant to the World Health Organization. The funders had no role in the study design or in the collection, analysis, or interpretation of the data. The funders did not write the report and had no role in the decision to submit the paper for publication. Authorship contributions: SAQ secured the funding. HM, JF, HN, HC, SAQ, and YBN conceptualised and designed the study, interpreted the data, and wrote the first draft of the manuscript. HM and YBN are responsible for the overall content and take full responsibility for the work, had access to the data, and made the decision to publish this article. YBN verified the underlying data and conducted the statistical analyses. All authors oversaw data collection, verified the underlying data, assisted with the interpretation of the data, and reviewed and provided input to the final draft. HM and YBN had final responsibility for the decision to submit for publication.
Publisher Copyright:
© World Health Organization [2022]. All rights reserved
PY - 2022
Y1 - 2022
N2 - Background The existing World Health Organization (WHO) pneumonia case management guidelines rely on clinical symptoms and signs for identifying, classifying, and treating pneumonia in children up to 5 years old. We aimed to collate an individual patient-level data set from large, high-quality pre-existing studies on pneumonia in children to identify a set of signs and symptoms with greater validity in the diagnosis, prognosis, and possible treatment of childhood pneumonia for the improvement of current pneumonia case management guidelines. Methods Using data from a published systematic review and expert knowledge, we identified studies meeting our eligibility criteria and invited investigators to share individual-level patient data. We collected data on demographic information, general medical history, and current illness episode, including history, clinical presentation, chest radiograph findings when available, treatment, and outcome. Data were gathered separately from hospital-based and community-based cases. We performed a narrative synthesis to describe the final data set. Results Forty-one separate data sets were included in the Pneumonia Research Partnership to Assess WHO Recommendations (PREPARE) database, 26 of which were hospital-based and 15 were community-based. The PREPARE database includes 285 839 children with pneumonia (244 323 in the hospital and 41 516 in the community), with detailed descriptions of clinical presentation, clinical progression, and outcome. Of 9185 pneumonia-related deaths, 6836 (74%) occurred in children <1 year of age and 1317 (14%) in children aged 1-2 years. Of the 285 839 episodes, 280 998 occurred in children 0-59 months old, of which 129 584 (46%) were 2-11 months of age and 152 730 (54%) were males.Conclusions This data set could identify an improved specific, sensitive set of criteria for diagnosing clinical pneumonia and help identify sick children in need of referral to a higher level of care or a change of therapy. Field studies could be designed based on insights from PREPARE analyses to validate a potential revised pneumonia algorithm. The PREPARE methodology can also act as a model for disease database assembly.
AB - Background The existing World Health Organization (WHO) pneumonia case management guidelines rely on clinical symptoms and signs for identifying, classifying, and treating pneumonia in children up to 5 years old. We aimed to collate an individual patient-level data set from large, high-quality pre-existing studies on pneumonia in children to identify a set of signs and symptoms with greater validity in the diagnosis, prognosis, and possible treatment of childhood pneumonia for the improvement of current pneumonia case management guidelines. Methods Using data from a published systematic review and expert knowledge, we identified studies meeting our eligibility criteria and invited investigators to share individual-level patient data. We collected data on demographic information, general medical history, and current illness episode, including history, clinical presentation, chest radiograph findings when available, treatment, and outcome. Data were gathered separately from hospital-based and community-based cases. We performed a narrative synthesis to describe the final data set. Results Forty-one separate data sets were included in the Pneumonia Research Partnership to Assess WHO Recommendations (PREPARE) database, 26 of which were hospital-based and 15 were community-based. The PREPARE database includes 285 839 children with pneumonia (244 323 in the hospital and 41 516 in the community), with detailed descriptions of clinical presentation, clinical progression, and outcome. Of 9185 pneumonia-related deaths, 6836 (74%) occurred in children <1 year of age and 1317 (14%) in children aged 1-2 years. Of the 285 839 episodes, 280 998 occurred in children 0-59 months old, of which 129 584 (46%) were 2-11 months of age and 152 730 (54%) were males.Conclusions This data set could identify an improved specific, sensitive set of criteria for diagnosing clinical pneumonia and help identify sick children in need of referral to a higher level of care or a change of therapy. Field studies could be designed based on insights from PREPARE analyses to validate a potential revised pneumonia algorithm. The PREPARE methodology can also act as a model for disease database assembly.
UR - http://www.scopus.com/inward/record.url?scp=85145090359&partnerID=8YFLogxK
U2 - 10.7189/JOGH.12.04075
DO - 10.7189/JOGH.12.04075
M3 - Article
C2 - 36579417
AN - SCOPUS:85145090359
SN - 2047-2978
VL - 12
JO - Journal of Global Health
JF - Journal of Global Health
M1 - 04075
ER -
