@article{337d0dbb107543a7ac3b09eb6626a621,
title = "Assessment and Validation of Syndromic Case Definitions for Respiratory Syncytial Virus Testing in a Low Resource Population",
abstract = "Standardized case definitions are needed in decision-making regarding respiratory syncytial virus control strategies, including vaccine evaluation. A syndromic case definition comprising of {"}wheeze or apnea or cyanosis{"} could be useful for community-based surveillance of moderate respiratory syncytial virus infection among young infants particularly in resource-limited settings. However, this definition showed modest specificity (29.2%-49.6%), indicating that community-based surveillance may need augmentation with other data.",
keywords = "RSV, surveillance, syndromic case definition",
author = "Omer, {Saad B.} and Robert Bednarczyk and Momin Kazi and {Beryl Guterman}, L. and Fatima Aziz and Allen, {Kristen E.} and Inci Yildirim and {Asad Ali}, S.",
note = "Funding Information: Accepted for publication June 2, 2018. From the *Hubert Department of Global Health, †Department of Epidemiology, ‡Department of Pediatrics, and §Emory Vaccine Center, Emory University, Atlanta, Georgia; and ¶Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Supported by a grant from the Bill & Melinda Gates Foundation (OPP1092014). The authors have no conflicts of interest to disclose. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal{\textquoteright}s Web site (www.pidj.com). Address for correspondence: Saad B. Omer, PhD, Department of Global Health, Emory University, 1518 Clifton Rd, Atlanta, GA 30322. E-mail: somer@ emory.edu. Copyright 2018 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribu-tion License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: 10.1097/INF.0000000000002159 Funding Information: This work was supported by grants UG3 OD-023253, U01 AI-087881, R01AI-114552, R01 AI-108588 and R21 HL-129909 from the National Institutes of Health (Bethesda, MD). The content of this manuscript is solely the respon-sibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2018 Wolters Kluwer Health, Inc. All rights reserved.",
year = "2019",
month = mar,
day = "1",
doi = "10.1097/INF.0000000000002159",
language = "English",
volume = "38",
pages = "E57--E59",
journal = "Pediatric Infectious Disease Journal",
issn = "0891-3668",
publisher = "Lippincott Williams and Wilkins Ltd.",
number = "3",
}
