Assessment of Cardiac, Vascular, and Pulmonary Pathobiology In Vivo During Acute COVID-19

Shirjel R. Alam, Sudhir Vinayak, Adeel Shah, Gemina Doolub, Redemptar Kimeu, Kevin P. Horn, Stephen R. Bowen, Mohamed Jeilan, Kuan Ken Lee, Sylvia Gachoka, Felix Riunga, Rodney D. Adam, Hubert Vesselle, Nikhil Joshi, Mariah Obino, Khalid Makhdomi, Kevin Ombati, Edward Nganga, Samuel Gitau, Michael H. ChungAnoop S.V. Shah

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Acute COVID-19– related myocardial, pulmonary, and vascular pathology and how these relate to each other remain unclear. To our knowledge, no studies have used complementary imaging techniques, including molecular imag-ing, to elucidate this. We used multimodality imaging and biochemical sampling in vivo to identify the pathobiology of acute COVID-19. Specifically, we investigated the presence of myocardial inflammation and its association with coronary artery disease, systemic vasculitis, and pneumonitis. METHODS AND RESULTS: Consecutive patients presenting with acute COVID-19 were prospectively recruited during hospital admission in this cross-sectional study. Imaging involved computed tomography coronary angiography (identified coronary disease), cardiac 2-deoxy-2-[fluorine-18]fluoro-D-glucose positron emission tomography/computed tomography (identified vascular, cardiac, and pulmonary inflammatory cell infiltration), and cardiac magnetic resonance (identified myocardial dis-ease) alongside biomarker sampling. Of 33 patients (median age 51 years, 94% men), 24 (73%) had respiratory symptoms, with the remainder having nonspecific viral symptoms. A total of 9 patients (35%, n=9/25) had cardiac magnetic resonance– defined myocarditis. Of these patients, 53% (n=5/8) had myocardial inflammatory cell infiltration. A total of 2 patients (5%) had elevated troponin levels. Cardiac troponin concentrations were not significantly higher in patients with and without myocarditis (8.4 ng/L [interquartile range, IQR: 4.0– 55.3] versus 3.5 ng/L [IQR: 2.5– 5.5]; P=0.07) or myocardial cell infiltration (4.4 ng/L [IQR: 3.4– 8.3] versus 3.5 ng/L [IQR: 2.8–7.2]; P=0.89). No patients had obstructive coronary artery disease or vasculitis. Pulmonary inflammation and consolidation (percentage of total lung volume) was 17% (IQR: 5%– 31%) and 11% (IQR: 7%–18%), respec-tively. Neither were associated with the presence of myocarditis. CONCLUSIONS: Myocarditis was present in a third patients with acute COVID-19, and the majority had inflammatory cell infil-tration. Pneumonitis was ubiquitous, but this inflammation was not associated with myocarditis. The mechanism of cardiac pathology is nonischemic and not attributable to a vasculitic process. REGISTRATION: URL: https://www.isrctn.com; Unique identifier: ISRCTN12154994.

Original languageEnglish
Article numbere026399
JournalJournal of the American Heart Association
Volume11
Issue number18
DOIs
Publication statusPublished - 20 Sept 2022

Keywords

  • CMR
  • COVID-19
  • FDG-PET
  • myocarditis
  • pneumonitis

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