Assessment of empagliflozin add-on therapy to metformin and glimepiride in patients with inadequately controlled type-2 diabetes mellitus

Bilal Jawed, Shadab Ahmed, Syed Qamar Abbas, Zeeshan Ahmed, Shomaiza Andleeb, Salman Ashfaq Ahmad, Muhammad Asif, Erum Akhter, Salman Ahmed, Muhammad Waleed Hussain, Adnan Iqbal, Azfar Athar Ishaqui

Research output: Contribution to journalArticlepeer-review

Abstract

Diabetes mellitus is a multifaceted metabolic disorder, which often required frequent blood glucose monitoring, poly-pharmacy and timely adjustments for its management. The present study focuses to check the effectiveness of empagliflozin add-on therapy in diabetic patients already taking metformin and glimepiride. This was observational, comparative and follow-up cohort study, conducted in a tertiary care hospital of Pakistan. Ninety subjects were enrolled and evenly distributed in Group A (patients on oral therapy of Metformin & Glimepiride) and Group B (patients on oral therapy of metformin, glimepiride and empagliflozin) randomly. The results showed that the addition of empagliflozin to metformin and glimepiride standard therapy provided better control over blood sugar with a significant decrease in HbA1c (16.1% decrease in HbA1c for Group B patients against 8.2% in Group A patients), FBS (23.8% decrease as compared to 14.6% decrease) and BMI (1.5% decrease in Group B patients against 0.06% increase in Group A). The addition of empagliflozin did not exacerbate the toxicity of the existing regimen and is safe to be included in multiple drug regimens. Empagliflozin addition to standard antidiabetic therapy might possess beneficial impacts in managing poorly controlled Type-2 Diabetes Mellitus in the Pakistani population.

Original languageEnglish
Pages (from-to)1733-1738
Number of pages6
JournalPakistan Journal of Pharmaceutical Sciences
Volume35
Issue number6
DOIs
Publication statusPublished - Nov 2022
Externally publishedYes

Keywords

  • Empagliflozin
  • HbA1c
  • diabetes mellitus
  • glimepiride
  • metformin

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