Association between circulating Galectin-3 and arterial stiffness in older adults: Atherosclerosis Risk in Communities (ARIC) Study

Xiaoming Jia, Caroline Sun, Hirofumi Tanaka, Mahmoud Al Rifai, David Aguilar, Chiadi Ndumele, Elizabeth Selvin, Salim S. Virani, Ron C. Hoogeveen, Gerardo Heiss, Christie M. Ballantyne, Vijay Nambi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Background: Galectin-3 (gal-3) is a β-galactoside-binding lectin associated tissue fibrosis and inflammation. There is limited understanding of the relationship between gal-3 and vascular health. Our aim was to assess the association between gal-3 and arterial stiffness in older adults. Methods: We conducted a cross-sectional study of 4275 participants (mean age of 75 years) from the Atherosclerosis Risk in Communities (ARIC) Study. Central arterial stiffness was measured by carotid-femoral pulse wave velocity (cfPWV). We evaluated the association of gal-3 with cfPWV using multivariable linear regression. Results: The median (interquartile range) gal-3 concentration was 16.5 (13.8, 19.8) ng/mL and mean cfPWV was 1163303 cm/s. Higher gal-3 concentration was associated with greater central arterial stiffness after adjustment for age, sex, race-center, heart rate, systolic blood pressure, anti-hypertensive medication use, and current smoking status (β=36.4 cm/s change in cfPWV per log unit change in gal-3; 95% CI: 7.2, 65.5, p=0.015). The association was attenuated after adjusting for additional cardiovascular risk factors (β=17.3, 95% CI: -14.4, 49.0). Conclusions: In community-dwelling older adults, gal-3 concentration was associated with central arterial stiffness, likely sharing common pathways with traditional cardiovascular risk factors.

Original languageEnglish
Pages (from-to)439-445
Number of pages7
JournalVasa - European Journal of Vascular Medicine
Volume50
Issue number6
DOIs
Publication statusPublished - Nov 2021
Externally publishedYes

Keywords

  • Galectin-3
  • aging
  • arterial stiffness

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