TY - JOUR
T1 - Association of alkaline phosphatase with acute myocardial infarction in a population with high prevalence of hypovitaminosis D
AU - Iqbal, Mohammad Perwaiz
AU - Mehboobali, Naseema
AU - Azam, Iqbal
AU - Tareen, Asal Khan
N1 - Funding Information:
This work was supported by a grant from the Pakistan Academy of Sciences/HEC . Technical help by Dr. Sahar Tariq in collecting some of the samples is appreciated. We acknowledge Ms. Dilshad Noorali, Assistant Professor, Center of English Language, Aga Khan University for editing this manuscript.
PY - 2013/10/1
Y1 - 2013/10/1
N2 - Background: Since Pakistanis have high prevalence of hypovitaminosis-D as well as acute myocardial infarction (AMI), the objective of the study was to investigate the relationship between vitamin-D deficiency and risk of AMI in a hospital-based population and to identify major risk factors for this disease. Methods: Fasting serum samples from 66 consecutive AMI patients [age 30-70. y] and 132 gender and age-matched (within 5. y) healthy controls were analyzed for concentrations of glucose, total-cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, calcium, inorganic phosphate, alkaline phosphatase (ALP), bone-ALP, parathyroid hormone (PTH), 25(OH) vitamin-D (25(OH)D) and alanine aminotransferase. Results: Mean concentrations of serum 25(OH)D, PTH, total-ALP, bone-ALP, LDL-cholesterol, HDL-cholesterol and glucose were significantly different compared to healthy controls (p. <. 0.05). Percent vitamin-D deficiency/insufficiency (levels. <. 30. ng/ml) was significantly greater in AMI patients compared to controls (93.9% vs.75.8%; p. = 0.001). Multiple conditional logistic regression analysis revealed that increased levels of 25(OH)D were associated with decreased risk of AMI [MAOR (95% CI). = 0.821 (0.718, 0.940); p. = 0.004]. Hypertension and smoking were positively associated with AMI. Conclusions: Increased vitamin-D levels were associated with decreased risk of AMI, while serum glucose, bone-ALP, hypertension and smoking were positively associated with it. Association of bone-ALP with AMI in hypovitaminosis-D is a novel finding of this study.
AB - Background: Since Pakistanis have high prevalence of hypovitaminosis-D as well as acute myocardial infarction (AMI), the objective of the study was to investigate the relationship between vitamin-D deficiency and risk of AMI in a hospital-based population and to identify major risk factors for this disease. Methods: Fasting serum samples from 66 consecutive AMI patients [age 30-70. y] and 132 gender and age-matched (within 5. y) healthy controls were analyzed for concentrations of glucose, total-cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, calcium, inorganic phosphate, alkaline phosphatase (ALP), bone-ALP, parathyroid hormone (PTH), 25(OH) vitamin-D (25(OH)D) and alanine aminotransferase. Results: Mean concentrations of serum 25(OH)D, PTH, total-ALP, bone-ALP, LDL-cholesterol, HDL-cholesterol and glucose were significantly different compared to healthy controls (p. <. 0.05). Percent vitamin-D deficiency/insufficiency (levels. <. 30. ng/ml) was significantly greater in AMI patients compared to controls (93.9% vs.75.8%; p. = 0.001). Multiple conditional logistic regression analysis revealed that increased levels of 25(OH)D were associated with decreased risk of AMI [MAOR (95% CI). = 0.821 (0.718, 0.940); p. = 0.004]. Hypertension and smoking were positively associated with AMI. Conclusions: Increased vitamin-D levels were associated with decreased risk of AMI, while serum glucose, bone-ALP, hypertension and smoking were positively associated with it. Association of bone-ALP with AMI in hypovitaminosis-D is a novel finding of this study.
KW - Acute myocardial infarction
KW - Alkaline phosphatase
KW - Bone alkaline phosphatase
KW - Coronary heart disease
KW - Hypovitaminosis D
KW - Vitamin D deficiency
UR - http://www.scopus.com/inward/record.url?scp=84883407449&partnerID=8YFLogxK
U2 - 10.1016/j.cca.2013.08.009
DO - 10.1016/j.cca.2013.08.009
M3 - Article
C2 - 23954837
AN - SCOPUS:84883407449
SN - 0009-8981
VL - 425
SP - 192
EP - 195
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
ER -