Association of TLL1 gene polymorphism (rs1503298, T > C) with coronary heart disease in PREDICT, UDACS and ED Cohorts

Maryam Zain, Fazli Rabbi Awan, Jackie A. Cooper, Ka Wah Li, Jutta Palmen, Jay Acharya, Philip Howard, Shahid M. Baig, Robert S. Elkeles, Jeffrey W. Stephens, Helen Ireland, Steve E. Humphries

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4 Citations (Scopus)


Objective: To determine the sequence variant of TLL1 gene (rs1503298, T > C) in three British cohorts (PREDICT, UDACS and ED) of patients with type-2 Diabetes mellitus (T2DM) in order to assess its association with coronary heart disease (CHD). Study Design: Analytical study. Place and Duration of Study: UCL, London, UK. Participants were genotyped in 2011-2012 for TLL1 SNP. Samples and related information were previously collected in 2001-2003 for PREDICT, and in 2001-2002 for UDACS and ED groups. Methodology: Patients included in PREDICT (n=600), UDACS (n=1020) and ED (n=1240) had Diabetes. TLL1 SNP (rs1503298, T > C) was genotyped using TaqMan technology. Allele frequencies were compared using χ2 test, and tested for Hardy-Weinberg equilibrium. The risk of disease was assessed from Odds ratios (OR) with 95% Confidence Intervals (95% CI). Moreover, for the PREDICT cohort, the SNP association was tested with Coronary Artery Calcification (CAC) scores. Results: No significant association was found for this SNP with CHD or CAC scores in these cohorts. Conclusion: This SNP could not be confirmed as a risk factor for CHD in T2DM patients. However, the low power of the small sample size available is a limitation to the modest effect on risk. Further studies in larger samples would be useful.

Original languageEnglish
Pages (from-to)615-619
Number of pages5
JournalJournal of the College of Physicians and Surgeons--Pakistan : JCPSP
Issue number9
Publication statusPublished - 2014
Externally publishedYes


  • Coronary artery calcification (CAC) score
  • Coronary heart disease
  • Diabetes mellitus
  • TLL1
  • rs1503298


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