Association of Vitamin D with outcome after intra cytoplasmic sperm injection

Umme Hani Abdullah, Salima Lalani, Fatima Syed, Sara Arif, Rehana Rehman

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Objective: To observe effects of vitamin D levels on pregnancy outcome after intra cytoplasmic sperm injection (ICSI). Method: It was a cross-sectional study conducted in Australian Concept Infertility Medical Center from July 2011 to August 2014. Estimation of 25-hydroxy cholecalciferol (25-OHD) of consented females (252) was done before treatment protocol for ICSI. Results of β hCG performed 14 days after embryo transfer categorized groups; Pregnant with ß hCG more than 25 IU/mL and rest included in non-pregnant group. Both groups were compared by independent sample t-test and Pearson’s Chi Square test. Binary Logistic Regression Analysis was used to estimate odds ratio of pregnancy outcome with its predictors including Vitamin D. Results: The mean value of 25-OHD, number of oocytes, fertilized oocytes and endometrial thickness was significantly higher in pregnant women. A significant positive association of 25-OHD with clinical pregnancy and thickness of endometrium was observed. After adjustment with female age and BMI, positive association of vitamin D with endometrial thickness was observed. Conclusion: Deficiency of 25-OHD in females hinders the accomplishment of optimal endometrial thickness required for implantation of embryo after ICSI. The improvement in vitamin D status can thus improve success results in assisted reproductive clinics.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number1
Publication statusPublished - 2 Jan 2017


  • Assisted reproductive techniques
  • Infertility
  • Vitamin D
  • intracytoplasmic sperm injection (ICSI)


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