Autoantibody levels are associated with acute kidney injury, anemia and post-discharge morbidity and mortality in Ugandan children with severe malaria

Juan Rivera- Correa, Andrea L. Conroy, Robert Opoka, Anthony Batte, Ruth Namazzi, Benson Ouma, Paul Bangirana, Richard Idro, Andrew L. Schwaderer, Chandy C. John, Ana Rodriguez

Research output: Contribution to journalArticle

Abstract

Autoantibodies targeting host antigens contribute to autoimmune disorders, frequently occur during and after infections and have been proposed to contribute to malaria-induced anemia. We measured anti-phosphatidylserine (PS) and anti-DNA antibody levels in 382 Ugandan children prospectively recruited in a study of severe malaria (SM). High antibody levels were defined as antibody levels greater than the mean plus 3 standard deviations of community children (CC). We observed increases in median levels of anti-PS and anti-DNA antibodies in children with SM compared to CC (p 

Original languageUndefined/Unknown
JournalPaediatrics and Child Health, East Africa
DOIs
Publication statusPublished - 1 Oct 2019

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