Autoantibody levels are associated with acute kidney injury, anemia and post-discharge morbidity and mortality in Ugandan children with severe malaria

Juan Rivera- Correa; Andrea L. Conroy; Robert Opoka; Anthony Batte; Ruth Namazzi; Benson Ouma; Paul Bangirana; Richard Idro; Andrew L. Schwaderer; Chandy C. John; Ana Rodriguez

doi:10.1038/s41598-019-51426-z

Autoantibody levels are associated with acute kidney injury, anemia and post-discharge morbidity and mortality in Ugandan children with severe malaria

Juan Rivera- Correa, Andrea L. Conroy, Robert Opoka, Anthony Batte, Ruth Namazzi, Benson Ouma, Paul Bangirana, Richard Idro, Andrew L. Schwaderer, Chandy C. John, Ana Rodriguez

Medical College, East Africa

Research output: Contribution to journal › Article

31 Citations (Scopus)

Abstract

Autoantibodies targeting host antigens contribute to autoimmune disorders, frequently occur during and after infections and have been proposed to contribute to malaria-induced anemia. We measured anti-phosphatidylserine (PS) and anti-DNA antibody levels in 382 Ugandan children prospectively recruited in a study of severe malaria (SM). High antibody levels were defined as antibody levels greater than the mean plus 3 standard deviations of community children (CC). We observed increases in median levels of anti-PS and anti-DNA antibodies in children with SM compared to CC (p

Original language	Undefined/Unknown
Journal	Paediatrics and Child Health, East Africa
DOIs	https://doi.org/10.1038/s41598-019-51426-z
Publication status	Published - 1 Oct 2019

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10.1038/s41598-019-51426-zLicence: Unspecified

http://ecommons.aku.edu/eastafrica_fhs_mc_paediatr_child_health/352

Cite this

Correa, J. R., Conroy, A. L., Opoka, R., Batte, A., Namazzi, R., Ouma, B., Bangirana, P., Idro, R., Schwaderer, A. L., John, C. C., & Rodriguez, A. (2019). Autoantibody levels are associated with acute kidney injury, anemia and post-discharge morbidity and mortality in Ugandan children with severe malaria. Paediatrics and Child Health, East Africa. https://doi.org/10.1038/s41598-019-51426-z

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abstract = "Autoantibodies targeting host antigens contribute to autoimmune disorders, frequently occur during and after infections and have been proposed to contribute to malaria-induced anemia. We measured anti-phosphatidylserine (PS) and anti-DNA antibody levels in 382 Ugandan children prospectively recruited in a study of severe malaria (SM). High antibody levels were defined as antibody levels greater than the mean plus 3 standard deviations of community children (CC). We observed increases in median levels of anti-PS and anti-DNA antibodies in children with SM compared to CC (p ",

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Correa, JR, Conroy, AL, Opoka, R, Batte, A, Namazzi, R, Ouma, B, Bangirana, P, Idro, R, Schwaderer, AL, John, CC & Rodriguez, A 2019, 'Autoantibody levels are associated with acute kidney injury, anemia and post-discharge morbidity and mortality in Ugandan children with severe malaria', Paediatrics and Child Health, East Africa. https://doi.org/10.1038/s41598-019-51426-z

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T1 - Autoantibody levels are associated with acute kidney injury, anemia and post-discharge morbidity and mortality in Ugandan children with severe malaria

AU - Correa, Juan Rivera-

AU - Conroy, Andrea L.

AU - Opoka, Robert

AU - Batte, Anthony

AU - Namazzi, Ruth

AU - Ouma, Benson

AU - Bangirana, Paul

AU - Idro, Richard

AU - Schwaderer, Andrew L.

AU - John, Chandy C.

AU - Rodriguez, Ana

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Autoantibodies targeting host antigens contribute to autoimmune disorders, frequently occur during and after infections and have been proposed to contribute to malaria-induced anemia. We measured anti-phosphatidylserine (PS) and anti-DNA antibody levels in 382 Ugandan children prospectively recruited in a study of severe malaria (SM). High antibody levels were defined as antibody levels greater than the mean plus 3 standard deviations of community children (CC). We observed increases in median levels of anti-PS and anti-DNA antibodies in children with SM compared to CC (p

AB - Autoantibodies targeting host antigens contribute to autoimmune disorders, frequently occur during and after infections and have been proposed to contribute to malaria-induced anemia. We measured anti-phosphatidylserine (PS) and anti-DNA antibody levels in 382 Ugandan children prospectively recruited in a study of severe malaria (SM). High antibody levels were defined as antibody levels greater than the mean plus 3 standard deviations of community children (CC). We observed increases in median levels of anti-PS and anti-DNA antibodies in children with SM compared to CC (p

U2 - 10.1038/s41598-019-51426-z

DO - 10.1038/s41598-019-51426-z

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JO - Paediatrics and Child Health, East Africa

JF - Paediatrics and Child Health, East Africa

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