Autologous hematopoietic stem cell transplantation —10 years of data from a developing country

Natasha Ali, Salman Naseem Adil, Mohammad Usman Shaikh

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Intensive chemotherapy followed by autologous stem cell transplantation is the treatment of choice for patients with hematological malignancies. The objective of the present study was to evaluate the outcomes of patients with mainly lymphoma and multiple myeloma after autologous stem cell transplant. The pretransplant workup consisted of the complete blood count, an evaluation of the liver, kidney, lung, and infectious profile, chest radiographs, and a dental review. For lymphoma, all patientswho achieved at least a 25%reduction in the disease after salvage therapywere included in the study. Mobilization was done with cyclophosphamide, followed by granulocyte colonystimulating factor, 300 µg twice daily. The conditioning regimens included BEAM (carmustine, etoposide, cytarabine, melphalan) and high-dose melphalan. A total of 206 transplants were performed from April 2004 to December 2014. Of these, 137 were allogeneic transplants and 69 were autologous. Of the patients receiving an autologous transplant, 49 were male and 20 were female. Of the 69 patients, 26 underwent transplantation for Hodgkin’s lymphoma, 23 for non-Hodgkin’s lymphoma, and 15 formultiplemyelomaand 4 and 1 forEwing’s sarcoma and neuroblastoma, respectively. The median age ± SD was 34 ± 13.1 years (range, 4–64). A mean of 4.7×108 ± 1.7 mononuclear cells per kilogram were infused. The median time to white blood cell recovery was 18.2 ± 5.34 days. Transplant-related mortality occurred in 10 patients. After a median follow-up period of 104 months, the overall survival rate was 86%. High-dose chemotherapy, followed by autologous stem cell transplant, is an effective treatment option for patients with hematological malignancies, allowing further consolidation of response.

Original languageEnglish
Pages (from-to)873-877
Number of pages5
JournalStem cells translational medicine
Volume4
Issue number8
DOIs
Publication statusPublished - 27 Jul 2015

Keywords

  • Autologous transplant
  • Lymphoma
  • Multiple myeloma

Fingerprint

Dive into the research topics of 'Autologous hematopoietic stem cell transplantation —10 years of data from a developing country'. Together they form a unique fingerprint.

Cite this