Averting a malaria disaster in Africa - Where does the buck stop?

Christopher J.M. Whitty, Richard Allan, Virginia Wiseman, Sam Ochola, Maria Veronicah Nakyanzi-Mugisha, Benjamin Vonhm, Mahemba Mwita, Constantin Miaka, Aggrey Oloo, Zul Premji, Craig Burgess, Theonest K. Mutabingwa

Research output: Contribution to journalReview articlepeer-review

36 Citations (Scopus)


The serious threat posed by the spread of drug-resistant malaria in Africa has been widely acknowledged. Chloroquine resistance is now almost universal, and resistance to the successor drug, sulfadoxine-pyrimethamine (SP), is growing rapidly. Combination therapy has been suggested as being an available and potentially lasting solution to this impending crisis. However, the current cost of combination therapy, and especially that of artemisinin combination therapy (ACT), is potentially a serious drawback, even if a significant part of its cost is passed on to the end-user. If the question of cost is not successfully addressed this could lead to adverse results from the deployment of combination therapy as first-line treatment. These adverse effects range from an increase in potentially fatal delays in infected individuals presenting to medical services, to exclusion of the poorest malaria sufferers from receiving treatment altogether. Urgent steps are needed to reduce the cost of combination therapy to the end-user in a sustainable way if it is to be usable, and some possible approaches are discussed.

Original languageEnglish
Pages (from-to)381-384
Number of pages4
JournalBulletin of the World Health Organization
Issue number5
Publication statusPublished - May 2004
Externally publishedYes


  • Africa
  • Antimalarials/economics
  • Artemisinins/economics
  • Drug costs
  • Drug therapy, Combination
  • Financing, Organized
  • Malaria, Falciparum/drug therapy
  • Patient acceptance of health care


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