TY - JOUR
T1 - Bacterial vaginosis is associated with uterine cervical human papillomavirus infection
T2 - A meta-analysis
AU - Gillet, Evy
AU - Meys, Joris F.A.
AU - Verstraelen, Hans
AU - Bosire, Carolyne
AU - De Sutter, Philippe
AU - Temmerman, Marleen
AU - Broeck, Davy V.
N1 - Funding Information:
DVB has a post-doctoral fellowship of the Research Foundation - Flanders (FWO). Part of this work was supported by the FWO.
PY - 2011/1/11
Y1 - 2011/1/11
N2 - Background: Bacterial vaginosis (BV), an alteration of vaginal flora involving a decrease in Lactobacilli and predominance of anaerobic bacteria, is among the most common cause of vaginal complaints for women of childbearing age. It is well known that BV has an influence in acquisition of certain genital infections. However, association between BV and cervical human papillomavirus (HPV) infection has been inconsistent among studies. The objective of this meta-analysis of published studies is to clarify and summarize published literature on the extent to which BV is associated with cervical HPV infection.Methods: Medline and Web of Science were systematically searched for eligible publications until December 2009. Articles were selected based on inclusion and exclusion criteria. After testing heterogeneity of studies, meta-analysis was performed using random effect model.Results: Twelve eligible studies were selected to review the association between BV and HPV, including a total of 6,372 women. The pooled prevalence of BV was 32%. The overall estimated odds ratio (OR) showed a positive association between BV and cervical HPV infection (OR, 1.43; 95% confidence interval, 1.11-1.84).Conclusion: This meta-analysis of available literature resulted in a positive association between BV and uterine cervical HPV infection.
AB - Background: Bacterial vaginosis (BV), an alteration of vaginal flora involving a decrease in Lactobacilli and predominance of anaerobic bacteria, is among the most common cause of vaginal complaints for women of childbearing age. It is well known that BV has an influence in acquisition of certain genital infections. However, association between BV and cervical human papillomavirus (HPV) infection has been inconsistent among studies. The objective of this meta-analysis of published studies is to clarify and summarize published literature on the extent to which BV is associated with cervical HPV infection.Methods: Medline and Web of Science were systematically searched for eligible publications until December 2009. Articles were selected based on inclusion and exclusion criteria. After testing heterogeneity of studies, meta-analysis was performed using random effect model.Results: Twelve eligible studies were selected to review the association between BV and HPV, including a total of 6,372 women. The pooled prevalence of BV was 32%. The overall estimated odds ratio (OR) showed a positive association between BV and cervical HPV infection (OR, 1.43; 95% confidence interval, 1.11-1.84).Conclusion: This meta-analysis of available literature resulted in a positive association between BV and uterine cervical HPV infection.
UR - http://www.scopus.com/inward/record.url?scp=78651106206&partnerID=8YFLogxK
U2 - 10.1186/1471-2334-11-10
DO - 10.1186/1471-2334-11-10
M3 - Article
C2 - 21223574
AN - SCOPUS:78651106206
SN - 1471-2334
VL - 11
JO - BMC Infectious Diseases
JF - BMC Infectious Diseases
M1 - 10
ER -