Behavioral and neurochemical effects of amfonelic acid on the spontaneously diabetic Wistar-BB rat: Implications of impaired dopamine function

Qadeer Ahmad, Zulfiquar Merali

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

1. The purpose of this study was to investigate the hypothesis that the Spontaneously Diabetic Wistar-BB Rat (SDR) would manifest an altered behavioral and neurochemical response to the indirect dopamine (DA) agonist amfonelic acid (AFA). 2. The insulin treated male SDR (3-4 months diabetic) and matched controls were monitored for locomotor, floor (horizontal and lateral displacement) and rearing activity. Catecholamines and metabolites were analyzed using HPLC-EC. 3. Results obtained indicated that the SDR: i) is less sensitive to the behavioral effects of AFA than the controls; ii) following AFA treatment (1.0 mg/kg) a significantly greater depletion of dopamine in the striatum, hypothalamus, midbrain and olfactory bulbs as well as striatal norepinephrine was observed in the SDR as compared to controls. These results implicate a dysfunctional biosynthetic capacity for DA in the SDR.

Original languageEnglish
Pages (from-to)551-558
Number of pages8
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume13
Issue number3-4
DOIs
Publication statusPublished - 1989
Externally publishedYes

Keywords

  • Amfonelic Acid
  • Behavior
  • Diabetes Mellitus
  • Dopamine
  • Spontaneously Diabetic Wistar-BB Rat

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