Abstract
1. The purpose of this study was to investigate the hypothesis that the Spontaneously Diabetic Wistar-BB Rat (SDR) would manifest an altered behavioral and neurochemical response to the indirect dopamine (DA) agonist amfonelic acid (AFA). 2. The insulin treated male SDR (3-4 months diabetic) and matched controls were monitored for locomotor, floor (horizontal and lateral displacement) and rearing activity. Catecholamines and metabolites were analyzed using HPLC-EC. 3. Results obtained indicated that the SDR: i) is less sensitive to the behavioral effects of AFA than the controls; ii) following AFA treatment (1.0 mg/kg) a significantly greater depletion of dopamine in the striatum, hypothalamus, midbrain and olfactory bulbs as well as striatal norepinephrine was observed in the SDR as compared to controls. These results implicate a dysfunctional biosynthetic capacity for DA in the SDR.
Original language | English |
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Pages (from-to) | 551-558 |
Number of pages | 8 |
Journal | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
Volume | 13 |
Issue number | 3-4 |
DOIs | |
Publication status | Published - 1989 |
Externally published | Yes |
Keywords
- Amfonelic Acid
- Behavior
- Diabetes Mellitus
- Dopamine
- Spontaneously Diabetic Wistar-BB Rat