Behavioral and neurochemical effects of amfonelic acid on the spontaneously diabetic Wistar-BB rat: Implications of impaired dopamine function

Qadeer Ahmad; Zulfiquar Merali

doi:10.1016/0278-5846(89)90145-0

Behavioral and neurochemical effects of amfonelic acid on the spontaneously diabetic Wistar-BB rat: Implications of impaired dopamine function

Qadeer Ahmad, Zulfiquar Merali

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

1. The purpose of this study was to investigate the hypothesis that the Spontaneously Diabetic Wistar-BB Rat (SDR) would manifest an altered behavioral and neurochemical response to the indirect dopamine (DA) agonist amfonelic acid (AFA). 2. The insulin treated male SDR (3-4 months diabetic) and matched controls were monitored for locomotor, floor (horizontal and lateral displacement) and rearing activity. Catecholamines and metabolites were analyzed using HPLC-EC. 3. Results obtained indicated that the SDR: i) is less sensitive to the behavioral effects of AFA than the controls; ii) following AFA treatment (1.0 mg/kg) a significantly greater depletion of dopamine in the striatum, hypothalamus, midbrain and olfactory bulbs as well as striatal norepinephrine was observed in the SDR as compared to controls. These results implicate a dysfunctional biosynthetic capacity for DA in the SDR.

Original language	English (UK)
Pages (from-to)	551-558
Number of pages	8
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	13
Issue number	3-4
DOIs	https://doi.org/10.1016/0278-5846(89)90145-0
Publication status	Published - 1989
Externally published	Yes

Keywords

Amfonelic Acid
Behavior
Diabetes Mellitus
Dopamine
Spontaneously Diabetic Wistar-BB Rat

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0278-5846(89)90145-0

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@article{978391f4f9d9453189e3c5f42a40a851,

title = "Behavioral and neurochemical effects of amfonelic acid on the spontaneously diabetic Wistar-BB rat: Implications of impaired dopamine function",

abstract = "1. The purpose of this study was to investigate the hypothesis that the Spontaneously Diabetic Wistar-BB Rat (SDR) would manifest an altered behavioral and neurochemical response to the indirect dopamine (DA) agonist amfonelic acid (AFA). 2. The insulin treated male SDR (3-4 months diabetic) and matched controls were monitored for locomotor, floor (horizontal and lateral displacement) and rearing activity. Catecholamines and metabolites were analyzed using HPLC-EC. 3. Results obtained indicated that the SDR: i) is less sensitive to the behavioral effects of AFA than the controls; ii) following AFA treatment (1.0 mg/kg) a significantly greater depletion of dopamine in the striatum, hypothalamus, midbrain and olfactory bulbs as well as striatal norepinephrine was observed in the SDR as compared to controls. These results implicate a dysfunctional biosynthetic capacity for DA in the SDR.",

keywords = "Amfonelic Acid, Behavior, Diabetes Mellitus, Dopamine, Spontaneously Diabetic Wistar-BB Rat",

author = "Qadeer Ahmad and Zulfiquar Merali",

note = "Funding Information: This researchw as supported by a grant from the Medical Research Council of Canada.",

year = "1989",

doi = "10.1016/0278-5846(89)90145-0",

language = "English (UK)",

volume = "13",

pages = "551--558",

journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",

issn = "0278-5846",

publisher = "Elsevier Inc.",

number = "3-4",

}

TY - JOUR

T1 - Behavioral and neurochemical effects of amfonelic acid on the spontaneously diabetic Wistar-BB rat

T2 - Implications of impaired dopamine function

AU - Ahmad, Qadeer

AU - Merali, Zulfiquar

N1 - Funding Information: This researchw as supported by a grant from the Medical Research Council of Canada.

PY - 1989

Y1 - 1989

N2 - 1. The purpose of this study was to investigate the hypothesis that the Spontaneously Diabetic Wistar-BB Rat (SDR) would manifest an altered behavioral and neurochemical response to the indirect dopamine (DA) agonist amfonelic acid (AFA). 2. The insulin treated male SDR (3-4 months diabetic) and matched controls were monitored for locomotor, floor (horizontal and lateral displacement) and rearing activity. Catecholamines and metabolites were analyzed using HPLC-EC. 3. Results obtained indicated that the SDR: i) is less sensitive to the behavioral effects of AFA than the controls; ii) following AFA treatment (1.0 mg/kg) a significantly greater depletion of dopamine in the striatum, hypothalamus, midbrain and olfactory bulbs as well as striatal norepinephrine was observed in the SDR as compared to controls. These results implicate a dysfunctional biosynthetic capacity for DA in the SDR.

AB - 1. The purpose of this study was to investigate the hypothesis that the Spontaneously Diabetic Wistar-BB Rat (SDR) would manifest an altered behavioral and neurochemical response to the indirect dopamine (DA) agonist amfonelic acid (AFA). 2. The insulin treated male SDR (3-4 months diabetic) and matched controls were monitored for locomotor, floor (horizontal and lateral displacement) and rearing activity. Catecholamines and metabolites were analyzed using HPLC-EC. 3. Results obtained indicated that the SDR: i) is less sensitive to the behavioral effects of AFA than the controls; ii) following AFA treatment (1.0 mg/kg) a significantly greater depletion of dopamine in the striatum, hypothalamus, midbrain and olfactory bulbs as well as striatal norepinephrine was observed in the SDR as compared to controls. These results implicate a dysfunctional biosynthetic capacity for DA in the SDR.

KW - Amfonelic Acid

KW - Behavior

KW - Diabetes Mellitus

KW - Dopamine

KW - Spontaneously Diabetic Wistar-BB Rat

UR - https://www.scopus.com/pages/publications/0024349695

U2 - 10.1016/0278-5846(89)90145-0

DO - 10.1016/0278-5846(89)90145-0

M3 - Article

C2 - 2748878

AN - SCOPUS:0024349695

SN - 0278-5846

VL - 13

SP - 551

EP - 558

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

IS - 3-4

ER -

Behavioral and neurochemical effects of amfonelic acid on the spontaneously diabetic Wistar-BB rat: Implications of impaired dopamine function

Abstract

Keywords

UN SDGs

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