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Benign but recurrent: gigantomastia due to juvenile fibroadenoma and pseudoangiomatous stromal hyperplasia

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Abstract

We report the case of a young, nulliparous woman who presented with bilateral gigantomastia secondary to juvenile fibroadenomas and pseudoangiomatous stromal hyperplasia (PASH). Despite undergoing multiple lumpectomies and reduction mammoplasty, she developed recurrent disfiguring breast enlargement with a significant psychosocial impact. Imaging and biopsy confirmed the presence of benign fibroepithelial lesions without malignant features. Given the aggressive recurrence, she underwent bilateral nipple-sparing mastectomy with immediate implant and latissimus dorsi flap reconstruction. Histopathological examination revealed fibroadenomatoid change with stromal fibrosis and PASH-like areas. This case highlights the rare but aggressive behaviour of juvenile fibroadenomas with coexisting PASH and underscores the need for early definitive surgical intervention in select patients. A multidisciplinary, patient-centred approach is essential to address both clinical and psychosocial needs, especially in young women in conservative sociocultural contexts.

Original languageEnglish (US)
JournalBMJ Case Reports
Volume19
Issue number5
DOIs
Publication statusPublished - May 2026

Keywords

  • Breast surgery
  • Plastic and reconstructive surgery
  • Surgical Procedure, Operative

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