TY - JOUR
T1 - Betel quid chewing alters functional connectivity in frontal and default networks
T2 - A resting-state fMRI study
AU - Huang, Xiaojun
AU - Liu, Zhening
AU - Mwansisya, Tumbwene E.
AU - Pu, Weidan
AU - Zhou, Li
AU - Liu, Chang
AU - Chen, Xudong
AU - Rohrbaugh, Robert
AU - Marienfeld, Carla
AU - Xue, Zhimin
AU - Liu, Haihong
N1 - Publisher Copyright:
© 2016 International Society for Magnetic Resonance in Medicine
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Purpose: To explore the acute effect of betel quid (BQ) use on functional network connectivity by comparing the global functional brain networks and their subsets before and immediately after BQ chewing. Materials and Methods: Resting-state functional magnetic resonance imaging (fMRI) was performed in 27 healthy male participants before and just after chewing BQ on a 3.0T scanner with a gradient-echo echo planar imaging sequence. Independent component analysis (ICA) was used to determine components that represent the brain's functional networks and their spatial aspects of functional connectivity. A paired t-test was used for exploring the connectivity differences in each network before and after BQ chewing. Results: Sixteen networks were identified by ICA. Nine of them showed connectivity differences before and after BQ chewing (P < 0.05 false discovery rate corrected): (A) orbitofrontal, (B) left frontoparietal, (C) visual, (D) right frontoparietal, (E) anterior default mode, (F) medial frontal/anterior cingulate (G) frontotemporal, (H) occipital/parietal, (I) occipital/temporal/cerebellum. Moreover, networks A, B, C, D, G, H, and I showed increased connectivity, while networks E and F showed decreased connectivity in participants after BQ chewing compared to before chewing. Conclusion: The acute effects of BQ use appear to actively alter functional connectivity of frontal and default networks that are known to play a key role in addictive behavior. Level of Evidence: 2. J. Magn. Reson. Imaging 2017;45:157–166.
AB - Purpose: To explore the acute effect of betel quid (BQ) use on functional network connectivity by comparing the global functional brain networks and their subsets before and immediately after BQ chewing. Materials and Methods: Resting-state functional magnetic resonance imaging (fMRI) was performed in 27 healthy male participants before and just after chewing BQ on a 3.0T scanner with a gradient-echo echo planar imaging sequence. Independent component analysis (ICA) was used to determine components that represent the brain's functional networks and their spatial aspects of functional connectivity. A paired t-test was used for exploring the connectivity differences in each network before and after BQ chewing. Results: Sixteen networks were identified by ICA. Nine of them showed connectivity differences before and after BQ chewing (P < 0.05 false discovery rate corrected): (A) orbitofrontal, (B) left frontoparietal, (C) visual, (D) right frontoparietal, (E) anterior default mode, (F) medial frontal/anterior cingulate (G) frontotemporal, (H) occipital/parietal, (I) occipital/temporal/cerebellum. Moreover, networks A, B, C, D, G, H, and I showed increased connectivity, while networks E and F showed decreased connectivity in participants after BQ chewing compared to before chewing. Conclusion: The acute effects of BQ use appear to actively alter functional connectivity of frontal and default networks that are known to play a key role in addictive behavior. Level of Evidence: 2. J. Magn. Reson. Imaging 2017;45:157–166.
KW - betel quid
KW - default network
KW - frontal
KW - functional connectivity
KW - resting-state
UR - http://www.scopus.com/inward/record.url?scp=84971254639&partnerID=8YFLogxK
U2 - 10.1002/jmri.25322
DO - 10.1002/jmri.25322
M3 - Article
C2 - 27227967
AN - SCOPUS:84971254639
SN - 1053-1807
VL - 45
SP - 157
EP - 166
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 1
ER -