Bio-imaging and Photodynamic Therapy with Tetra Sulphonatophenyl Porphyrin (TSPP)-TiO 2 Nanowhiskers: New Approaches in Rheumatoid Arthritis Theranostics

Chunqiu Zhao; Fawad Ur Rehman; Yanlong Yang; Xiaoqi Li; Dong Zhang; Hui Jiang; Matthias Selke; Xuemei Wang; Chongyang Liu

doi:10.1038/srep11518

Bio-imaging and Photodynamic Therapy with Tetra Sulphonatophenyl Porphyrin (TSPP)-TiO 2 Nanowhiskers: New Approaches in Rheumatoid Arthritis Theranostics

Chunqiu Zhao, Fawad Ur Rehman, Yanlong Yang, Xiaoqi Li, Dong Zhang, Hui Jiang, Matthias Selke, Xuemei Wang, Chongyang Liu

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

Since Rheumatoid arthritis (RA) is one of the major human joint diseases with unknown etiology, the early diagnosis and treatment of RA remains a challenge. In this contribution we have explored the possibility to utilize novel nanocomposites of tetera suplhonatophenyl porphyrin (TSPP) with titanium dioxide (TiO 2) nanowhiskers (TP) as effective bio-imaging and photodynamic therapeutic (PDT) agent for RA theranostics. Our observations demonstrate that TP solution PDT have an ameliorating effect on the RA by decreasing significantly the IL-17 and TNF-α level in blood serum and fluorescent imaging could enable us to diagnose the disease in subclinical stages and bio-mark the RA insulted joint.

Original language	English (US)
Article number	11518
Journal	Scientific Reports
Volume	5
DOIs	https://doi.org/10.1038/srep11518
Publication status	Published - 8 Jul 2015
Externally published	Yes

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title = "Bio-imaging and Photodynamic Therapy with Tetra Sulphonatophenyl Porphyrin (TSPP)-TiO 2 Nanowhiskers: New Approaches in Rheumatoid Arthritis Theranostics",

abstract = "Since Rheumatoid arthritis (RA) is one of the major human joint diseases with unknown etiology, the early diagnosis and treatment of RA remains a challenge. In this contribution we have explored the possibility to utilize novel nanocomposites of tetera suplhonatophenyl porphyrin (TSPP) with titanium dioxide (TiO 2) nanowhiskers (TP) as effective bio-imaging and photodynamic therapeutic (PDT) agent for RA theranostics. Our observations demonstrate that TP solution PDT have an ameliorating effect on the RA by decreasing significantly the IL-17 and TNF-α level in blood serum and fluorescent imaging could enable us to diagnose the disease in subclinical stages and bio-mark the RA insulted joint.",

author = "Chunqiu Zhao and \{Ur Rehman\}, Fawad and Yanlong Yang and Xiaoqi Li and Dong Zhang and Hui Jiang and Matthias Selke and Xuemei Wang and Chongyang Liu",

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doi = "10.1038/srep11518",

language = "English (US)",

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journal = "Scientific Reports",

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T1 - Bio-imaging and Photodynamic Therapy with Tetra Sulphonatophenyl Porphyrin (TSPP)-TiO 2 Nanowhiskers

T2 - New Approaches in Rheumatoid Arthritis Theranostics

AU - Zhao, Chunqiu

AU - Ur Rehman, Fawad

AU - Yang, Yanlong

AU - Li, Xiaoqi

AU - Zhang, Dong

AU - Jiang, Hui

AU - Selke, Matthias

AU - Wang, Xuemei

AU - Liu, Chongyang

PY - 2015/7/8

Y1 - 2015/7/8

N2 - Since Rheumatoid arthritis (RA) is one of the major human joint diseases with unknown etiology, the early diagnosis and treatment of RA remains a challenge. In this contribution we have explored the possibility to utilize novel nanocomposites of tetera suplhonatophenyl porphyrin (TSPP) with titanium dioxide (TiO 2) nanowhiskers (TP) as effective bio-imaging and photodynamic therapeutic (PDT) agent for RA theranostics. Our observations demonstrate that TP solution PDT have an ameliorating effect on the RA by decreasing significantly the IL-17 and TNF-α level in blood serum and fluorescent imaging could enable us to diagnose the disease in subclinical stages and bio-mark the RA insulted joint.

AB - Since Rheumatoid arthritis (RA) is one of the major human joint diseases with unknown etiology, the early diagnosis and treatment of RA remains a challenge. In this contribution we have explored the possibility to utilize novel nanocomposites of tetera suplhonatophenyl porphyrin (TSPP) with titanium dioxide (TiO 2) nanowhiskers (TP) as effective bio-imaging and photodynamic therapeutic (PDT) agent for RA theranostics. Our observations demonstrate that TP solution PDT have an ameliorating effect on the RA by decreasing significantly the IL-17 and TNF-α level in blood serum and fluorescent imaging could enable us to diagnose the disease in subclinical stages and bio-mark the RA insulted joint.

UR - https://www.scopus.com/pages/publications/84936972641

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DO - 10.1038/srep11518

M3 - Article

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AN - SCOPUS:84936972641

SN - 2045-2322

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JO - Scientific Reports

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ER -

Bio-imaging and Photodynamic Therapy with Tetra Sulphonatophenyl Porphyrin (TSPP)-TiO 2 Nanowhiskers: New Approaches in Rheumatoid Arthritis Theranostics

Abstract

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