TY - JOUR
T1 - Biomarkers and degree of atherosclerosis are independently associated with incident atherosclerotic cardiovascular disease in a primary prevention cohort
T2 - The ARIC study
AU - Agarwala, Anandita
AU - Virani, Salim
AU - Couper, David
AU - Chambless, Lloyd
AU - Boerwinkle, Eric
AU - Astor, Brad C.
AU - Hoogeveen, Ron C.
AU - Coresh, Joe
AU - Sharrett, A. Richey
AU - Folsom, Aaron R.
AU - Mosley, Tom
AU - Ballantyne, Christie M.
AU - Nambi, Vijay
N1 - Publisher Copyright:
© 2016
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Background and aims Biomarkers and atherosclerosis imaging have been studied individually for association with incident cardiovascular disease (CVD); however, limited data exist on whether the biomarkers are associated with events with a similar magnitude in the presence of atherosclerosis. In this study, we assessed whether the presence of atherosclerosis as measured by carotid intima media thickness (cIMT) affects the association between biomarkers known to be associated with coronary heart disease (CHD) and incident cardiovascular disease (CVD) in a primary prevention cohort. Methods 8127 participants from the ARIC study (4th visit, 1996–1998) were stratified as having minimal, mild, or substantial atherosclerosis by cIMT. Levels of C-reactive protein, lipoprotein-associated phospholipase A2, cardiac troponin T, N-terminal pro-brain natriuretic peptide, lipoprotein(a), cystatin C, and urine albumin to creatinine ratio were measured in each participant. Hazard ratios were used to determine the relationship between the biomarkers and incident CHD, stroke, and CVD in each category of atherosclerosis. Results While each of the biomarkers was significantly associated with risk of events overall, we found no significant differences noted in the strength of association of biomarkers with CHD, stroke, and CVD when analyzed by degree of atherosclerosis. Conclusions These findings suggest that the level of atherosclerosis does not significantly influence the association between biomarkers and CVD.
AB - Background and aims Biomarkers and atherosclerosis imaging have been studied individually for association with incident cardiovascular disease (CVD); however, limited data exist on whether the biomarkers are associated with events with a similar magnitude in the presence of atherosclerosis. In this study, we assessed whether the presence of atherosclerosis as measured by carotid intima media thickness (cIMT) affects the association between biomarkers known to be associated with coronary heart disease (CHD) and incident cardiovascular disease (CVD) in a primary prevention cohort. Methods 8127 participants from the ARIC study (4th visit, 1996–1998) were stratified as having minimal, mild, or substantial atherosclerosis by cIMT. Levels of C-reactive protein, lipoprotein-associated phospholipase A2, cardiac troponin T, N-terminal pro-brain natriuretic peptide, lipoprotein(a), cystatin C, and urine albumin to creatinine ratio were measured in each participant. Hazard ratios were used to determine the relationship between the biomarkers and incident CHD, stroke, and CVD in each category of atherosclerosis. Results While each of the biomarkers was significantly associated with risk of events overall, we found no significant differences noted in the strength of association of biomarkers with CHD, stroke, and CVD when analyzed by degree of atherosclerosis. Conclusions These findings suggest that the level of atherosclerosis does not significantly influence the association between biomarkers and CVD.
KW - Cardiovascular disease
KW - Carotid intima media thickness
KW - Coronary heart disease
KW - High sensitivity C- reactive protein
KW - High sensitivity troponin T
KW - Lipoprotein associated phospholipase A2
KW - NT-pro B-type natriuretic peptide
KW - Stroke
KW - lipoprotein(a)
UR - http://www.scopus.com/inward/record.url?scp=84988481758&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2016.08.028
DO - 10.1016/j.atherosclerosis.2016.08.028
M3 - Article
C2 - 27665201
AN - SCOPUS:84988481758
SN - 0021-9150
VL - 253
SP - 156
EP - 163
JO - Atherosclerosis
JF - Atherosclerosis
ER -