BK polyomavirus virus hemorrhagic cystitis following allogeneic bone marrow transplant with haploidentical related donor: Case reports from two patients

Danish Shakeel, Natasha Bahadur Ali, Mohammad Usman Shaikh, Salman Adil

Research output: Other contribution

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Abstract

BK virus is well known to be associated with allograft failure in renal transplant recipients due to polyomavirus-associated nephropathy (PVAN). BK viruses are increasingly recognized an important cause of hemorrhagic cystitis during hematopoietic stem cell transplantation (HSCT). Here we describe two patients with acute lymphoblastic leukemia who received a haplo identical match related donor hematopoietic stem cell transplant after myeloablative conditioning and post-transplant cyclophosphamide. They developed cytology proven BK Virus cystitis. Both were treated with Leflunomide. Treatment was effective in alleviating the symptoms temporarily but eventually the symptoms progressed and resulted in mortality of both patients.

Original languageUndefined/Unknown
Publication statusPublished - 5 Oct 2017

Publication series

NameSection of Haematology/Oncology

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